Development of a hemostatic wound dressing incorporating lyophilized platelets

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$100,000.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-05-C-0057
Award Id:
76542
Agency Tracking Number:
O043-H17-3017
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
9430 Key West Avenue, Suite 210, Rockville, MD, 20850
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
137192840
Principal Investigator:
DavidHo
Senior Scientist
(301) 424-8344
dho@adlyfe.com
Business Contact:
RichardCliff
COO
(301) 424-8344
rcliff@adlyfe.com
Research Institute:
n/a
Abstract
The main goal of this proposal is to develop stabilized freeze-dried Yucatan pig platelets that will retain the majority of platelet biological properties, but can be stored in the dry state for years. These platelets will be incorporated into a hemostatic dressing that will control bleeding in the Yucatan pig wound and bone healing model. This proposal is based on the extensive amount of work already performed at Adlyfe, where stored human freeze-drying trehelose-loaded platelets, upon reconstitution with water, demonstrated normal response to physiological agonists as well as able to release growth factors in controlled spatial and temporal manner. In phase I, key structural and functional parameters will be measured in vitro to determine the efficacy of the freeze-dried Yucatan pig platelets as hemostatic agent. These studies will be critical toward the pre-clinical and clinical development of this important hemostat therapeutic proposed for Phase II.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government