Development of a hemostatic wound dressing incorporating lyophilized platelets

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-05-C-0057
Agency Tracking Number: O043-H17-3017
Amount: $100,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2005
Solicitation Year: 2004
Solicitation Topic Code: OSD04-H17
Solicitation Number: 2004.3
Small Business Information
9430 Key West Avenue, Suite 210, Rockville, MD, 20850
DUNS: 137192840
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 David Ho
 Senior Scientist
 (301) 424-8344
Business Contact
 Richard Cliff
Title: COO
Phone: (301) 424-8344
Research Institution
The main goal of this proposal is to develop stabilized freeze-dried Yucatan pig platelets that will retain the majority of platelet biological properties, but can be stored in the dry state for years. These platelets will be incorporated into a hemostatic dressing that will control bleeding in the Yucatan pig wound and bone healing model. This proposal is based on the extensive amount of work already performed at Adlyfe, where stored human freeze-drying trehelose-loaded platelets, upon reconstitution with water, demonstrated normal response to physiological agonists as well as able to release growth factors in controlled spatial and temporal manner. In phase I, key structural and functional parameters will be measured in vitro to determine the efficacy of the freeze-dried Yucatan pig platelets as hemostatic agent. These studies will be critical toward the pre-clinical and clinical development of this important hemostat therapeutic proposed for Phase II.

* Information listed above is at the time of submission. *

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