Scientific Basis for Topical Silver Fluoride in Dentistry

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$96,096.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
1R43DE019268-01
Award Id:
89055
Agency Tracking Number:
DE019268
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ADP SILVER DENTAL ARREST, LLC, 442 SW UMATILLA AVE, STE 200, REDMOND, OR, 97756
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
805599441
Principal Investigator:
() -
Business Contact:
() -
mikes@advantagedental.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The overall purpose of this Phase I SBIR application is conduct of research to address the scientific and technical feasibility of using diammine (also spelled diamine in the literature) silver fluoride as a topical age nt to arrest the progression of tooth decay, and to conduct the initial work that, in the longer run, will result in FDA 510 K approval of an indication for diammine silver fluoride as a tooth decay arresting agent. The research will be conducted by a coll aboration of the small business firm ADP Silver Dental Arrest, LLC, and experienced researchers at the University of Connecticut School of Dental Medicine. The Specific Aims are to: 1) Use a human caries model experiment in well-characterized rats to deter mine whether a single brief topical diammine silver fluoride treatment can inhibit the progression of already-established extensive carious lesions and 2) Conduct a single dose topical administration study to assess potential toxicity of diammine silver fl uoride. Alarming new national epidemiologic data documents the increase in tooth decay in preschool children (Dye et al., 2007) at the same that there are serious inequities in access to care for the poor and for minorities. The same problem exists for the elderly and institutionalized where inexpensive solutions to arresting root caries are badly needed. Given increased disease impact in some parts of the population coupled with poor access, it is likely that the disparities will increase. New technology i s not being developed and brought to the marketplace fast enough to address the problem. Public Health Significance: The overall purpose of this Phase I SBIR application is conduct of research to address the scientific and technical feasibility of using di ammine (also spelled diamine in the literature) silver fluoride as a topical agent to arrest the progression of tooth decay, and to conduct the initial work that, in the longer run, will result in FDA 510 K approval of an indication for diammine silver flu oride as a tooth decay arresting agent.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government