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COCHLEAR ELECTRODE WITH HIGH CHANNEL SELECTIVITY
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DESCRIPTION: (Adapted from the applicant's abstract) Advanced Bionics is the only U.S. manufacturer of cochlear implants, which restore functional hearing to patients with profound sensorineural deafness. The CLARION implant employs the most sophisticated multichannel speech processing system available, but clinical performance of this and competing devices tends to be limited by relatively poor selectivity of the multichannel electrode. The external speech processor filters the acoustic signal into parallel channels of electrical stimulation that are intended to activate separate populations of auditory neurons when transmitted to the multichannel electrode implanted in the inner ear. A novel electrode has been designed that should substantially improve channel selectivity; a novel method for fabricating such electrodes has been developed. Animal-scale electrodes will be designed, built and implanted chronically in cats; post-mortem histological analysis will evaluate the safety of this novel strategy. Human-scale electrodes will be designed, built and tested for surgical handling properties. If feasibility is demonstrated, selective electrodes will then be evaluated in deaf patients as part of functional cochlear implant systems. The goal of this research is a substantial improvement in the quality of sound provided by cochlear implants, permitting an even higher percentage of recipients to function normally in hearing society. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 251 --PROJECT NUMBER......1 R43 DC03523-01 INVESTIGATOR NAME/ADDRESS FY 97 CROSS, RUSSELL T IRG/INTRAMURAL UNIT..ZRG1 PRENTKE ROMICH COMPANY AWARD AMOUNT......... $100,000 1022 HEYL ROAD WOOSTER, OH 44691 PERFORMING ORGANIZATION: PRENTKE ROMICH COMPANY TITLE APPLYING LANGUAGE WITH DYNAMIC SCREEN TECHNOLOGY ABSTRACT: DESCRIPTION: (Adapted from the applicant's abstract) There are many individuals with moderate to severe cognitive impairments who have real problems using communication aids to interact spontaneously. The development of technologies that use touch screens seemed to promise help to these people. However, this has not been realized to any significant extent. In the proposed project, the applicant will develop a voice output communication aid that will integrate hardware, software and a language representation system, in a new and exciting way. The system will be beta-tested with a number of non-speaking individuals who have moderate to severe cognitive disability. $ = TOTAL AWARD AMTS & NOT LIMITED TO PORTION OF PROJECT RELATED TO SUBJECT OF SEARCH SUBPROJECT $ = TOTAL AWARD AMOUNT DIVIDED BY NUMBER OF SUBPROJECTS SOURCE: CRISP FORMAT F FY 97 LAST UPDATE 04-07-98 1QUERY 1536 ID SEARCH 06/01/98 PAGE 252 --PROJECT NUMBER......2 R44 DK47761-02A1 INVESTIGATOR NAME/ADDRESS FY 97 LINGREN, CLINTON L IRG/INTRAMURAL UNIT..ZRG7 DIGIRAD CORP AWARD AMOUNT......... $368,730 7408 TRADE STREET SAN DIEGO, CA 92121-2410 PERFORMING ORGANIZATION: DIGIRAD TITLE INSTRUMENT FOR REAL TIME RENAL MONITORING ABSTRACT: The mortality rate for acute renal failure has not changed significantly during the last 25 years. This may be due in part, to the inability to adequately predict and identify the onset and causes of acute renal failure. Current measurement techniques cannot quickly identify changes in renal function; the time for measuring renal function is typically four hours. An accurate means for measuring renal function in real time (i.e.,measuring and seeing changes in renal function as they occur) should allow researchers to better understand the pathophysiology of acute renal failure and lead to significant reductions in mortality rate and in the number of persons requiring acute dialysis associated with acute renal failure. The goal of this proposal is: 1) to complete development of an instrument for measuring renal function in real time and 2) to validate the measurement accuracy and the response time for rapid changes in renal function. Making this instrument available to nephrologists should allow researchers to demonstrate the efficacy of real time renal monitoring in saving lives and reducing the number of those who require acute dialysis. This may lead to real-time renal monitoring of most intensive care and organ transplant patient.
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