SMALL MOLECULE BLOCKERS OF B. ANTHRACIS TOXIN

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43AI052894-01
Agency Tracking Number: AI052894
Amount: $106,498.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
ADVANCED BIOSYSTEMS, INC.
ADVANCED BIOSYSTEMS, INC., 10900 UNIVERSITY BLVD, MANASSAS, VA, 20110
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 VLADIMIR KARGINOV
 (703) 993-8455
 VLADIMIR.KARGINOV@HADRON.COM
Business Contact
 DEBORAH HICKOX
Phone: (703) 993-4287
Email: DEBORAH.HICKOX@HADRON.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): The overall goal of this SBIR proposal is the identification of small molecules capable of blocking the cytotoxic action of Bacillus anthracis lethal toxin by blocking the transmembrane pore formed by the protective antigen component of the toxin. Such molecules are envisioned for use as drugs for the treatment of anthrax. The strategy to identify such compounds involves developing an assay for testing the ability of compounds to inhibit the cytotoxic effect of anthrax toxin. A limited representative library of compounds will be designed and synthesized. The synthesized compounds will then be tested for inhibitory activity. The resulting baseline data will be used for computer-assisted design of compounds with improved affinity towards the transmembrane pore, followed by a second round of chemical synthesis and testing.

* information listed above is at the time of submission.

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