SMALL MOLECULE BLOCKERS OF B. ANTHRACIS TOXIN

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$106,498.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43AI052894-01
Award Id:
60465
Agency Tracking Number:
AI052894
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ADVANCED BIOSYSTEMS, INC., 10900 UNIVERSITY BLVD, MANASSAS, VA, 20110
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
VLADIMIR KARGINOV
(703) 993-8455
VLADIMIR.KARGINOV@HADRON.COM
Business Contact:
DEBORAH HICKOX
(703) 993-4287
DEBORAH.HICKOX@HADRON.COM
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): The overall goal of this SBIR proposal is the identification of small molecules capable of blocking the cytotoxic action of Bacillus anthracis lethal toxin by blocking the transmembrane pore formed by the protective antigen component of the toxin. Such molecules are envisioned for use as drugs for the treatment of anthrax. The strategy to identify such compounds involves developing an assay for testing the ability of compounds to inhibit the cytotoxic effect of anthrax toxin. A limited representative library of compounds will be designed and synthesized. The synthesized compounds will then be tested for inhibitory activity. The resulting baseline data will be used for computer-assisted design of compounds with improved affinity towards the transmembrane pore, followed by a second round of chemical synthesis and testing.

* information listed above is at the time of submission.

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