System for comprehensive tracking and analysis of C. elegans behaviors

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44ES017180-02
Agency Tracking Number: ES017180
Amount: $744,130.00
Phase: Phase II
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: NIEHS
Solicitation Number: PHS2010-2
Small Business Information
DUNS: 787008242
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (802) 288-9290
Business Contact
Phone: (802) 288-9290
Research Institution
DESCRIPTION (provided by applicant): We propose a commercial product composed of a computerized microscope system that allows investigators to perform automated, quantitative analyses of locomotory and other complex behaviors of freely moving C. elegans nematodes. Using the soil nematode, C. elegans, as a practical and efficient model in toxicology studies requires creation of automated technologies to evaluate growth, size, reproduction, feeding, and movement under different experimental conditions. Currently, most methods to assess C. elegans phenotypic behavior are manual and laborious to perform which precludes medium-throughput studies. We believe that introduction of this robust commercial software solution will significantly contribute to further replacement and reduction of conventional toxicology tests by alternative in vivo toxicology assays using C. elegans. PUBLIC HEALTH RELEVANCE: The proposed project will increase the throughput of studies involving quantitative behavioral analysis using the model organism Caenorhabditis elegans (C. elegans). This will allow researchers to automatically perform complex and laborious tasks which are presently performed manually. The overall effect of this project will significantly improve the productivity and effectiveness of research in such diverse fields as toxicology, environmental monitoring, ecology and neuroscience research.

* Information listed above is at the time of submission. *

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