System for comprehensive tracking and analysis of C. elegans behaviors

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$744,130.00
Award Year:
2010
Program:
SBIR
Phase:
Phase II
Contract:
2R44ES017180-02
Award Id:
89127
Agency Tracking Number:
ES017180
Solicitation Year:
n/a
Solicitation Topic Code:
NIEHS
Solicitation Number:
n/a
Small Business Information
MICROBRIGHTFIELD, INC., 185 ALLEN BROOK LN, STE 201, WILLISTON, VT, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
787008242
Principal Investigator:
JACOB GLASER
(802) 288-9290
JGLASER@MICROBRIGHTFIELD.COM
Business Contact:
JACOB GLASER
() -
susan@microbrightfield.com
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): We propose a commercial product composed of a computerized microscope system that allows investigators to perform automated, quantitative analyses of locomotory and other complex behaviors of freely moving C. elegans ne matodes. Using the soil nematode, C. elegans, as a practical and efficient model in toxicology studies requires creation of automated technologies to evaluate growth, size, reproduction, feeding, and movement under different experimental conditions. Curren tly, most methods to assess C. elegans phenotypic behavior are manual and laborious to perform which precludes medium-throughput studies. We believe that introduction of this robust commercial software solution will significantly contribute to further repl acement and reduction of conventional toxicology tests by alternative in vivo toxicology assays using C. elegans. PUBLIC HEALTH RELEVANCE: The proposed project will increase the throughput of studies involving quantitative behavioral analysis using the model organism Caenorhabditis elegans (C. elegans). This will allow researchers to automatically perform complex and laborious tasks which are presently performed manually. The overall effect of this project will significantly improve the productivity and effectiveness of research in such diverse fields as toxicology, environmental monitoring, ecology and neuroscience research.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government