Noninvasive Treatment of Hemorrhagic Shock

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-04-C-0022
Agency Tracking Number: A032-1971
Amount: $69,957.00
Phase: Phase I
Program: SBIR
Awards Year: 2004
Solicitation Year: 2003
Solicitation Topic Code: A03-178
Solicitation Number: 2003.2
Small Business Information
7615 Golden Triangle Drive Suite A, Eden Prairie, MN, 55344
DUNS: 140320396
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Keith Lurie
 Chief Medical Officer
 (612) 986-3917
Business Contact
 Mike Black
Title: Chief Financial Officer
Phone: (952) 947-9551
Research Institution
Hemorrhagic shock is the leading cause of death in combat injuries. This application focuses on a novel way to treat hemorrhagic shock using a new device called the inspiratory impedance threshold device (ITD). The ITD increases blood pressure and survival rates in animals in hemorrhagic shock. Phase I studies in human volunteers are intended to demonstrate proof of concept that use of the ITD is a) feasible, b) tolerable, and c) will increase cardiac stroke volume and stabilize blood pressure in normotensive and hypotensive subjects. In spontaneously breathing subjects the ITD creates a small vacuum within the chest, forcing more blood from the extra-thoracic veins into the heart with each inspiration. This results in an increase in blood pressure, without an immediate need for intravenous fluids or surgical intervention. Phase II studies will focus on use of the ITD in volunteers subjected to hypotension simulating battlefield shock in a lower body negative pressure chamber and in hypotensive patients in the emergency room. The studies are designed to demonstrate that the ITD can "buy time", until more definitive care is available. The studies will shed new light on the mechanisms and treatment of hemorrhagic shock, with important military and civilian applications.

* information listed above is at the time of submission.

Agency Micro-sites

US Flag An Official Website of the United States Government