Inspiratory Impedance as a Treatment for Traumatic Brain Injury

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$729,863.00
Award Year:
2008
Program:
SBIR
Phase:
Phase II
Contract:
W81XWH-07-C-0018
Award Id:
77486
Agency Tracking Number:
A062-150-0842
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
7615 Golden Triangle Drive Suite A, Eden Prairie, MN, 55344
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
140320396
Principal Investigator:
Keith Lurie
Chief Medical Officer
(612) 986-3917
klurie@advancedcirculatory.com
Business Contact:
Anja Metzger
Director of R&D and Grant
(651) 226-1626
ametzger@advancedcirculatory.com
Research Institution:
n/a
Abstract
Traumatic head and neck injuries account for 16-33% of all war-related injuries and are a leading cause of mortality upon evacuation to a definitive care setting. Therapeutic advances are urgently needed for these soldiers. This application is focused on treating one of the most important determinants of outcome from severe head injury, the degree and duration of elevated intracranial pressure (ICP). New research in our animal laboratory has discovered that lowering intrathoracic pressures can result in a significant lowering of ICP. Building upon the positive results of the Phase 1 studies, two of the major objectives of this Phase 2 proposal are to a) evaluate the longer-term application of the Intrathoracic Pressure Regulator (ITPR) in an animal model of brain injury and b) establish proof of concept that application of the Impedance Threshold Device (ITD) and ITPR will result in a decrease in ICP and an increase in cerebral perfusion pressures in patients in need of increased brain perfusion. The successful development and deployment of a new device designed to immediately increase cerebral perfusion pressures or decrease elevated ICP or prevent the onset of elevated ICP following traumatic brain injury would be a major advance in treating battlefield head injuries.

* information listed above is at the time of submission.

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