MULTIRESOLUTION AUTOFOCUSING FOR AUTOMATED CYTOGENETICS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$91,727.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43RR016817-01
Agency Tracking Number:
RR016817
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
ADVANCED DIGITAL IMAGING RESEARCH, LLC
ADVANCED DIGITAL IMAGING RES, 2450 S SHORE BLVD, STE 305, LEAGUE CITY, TX, 77573
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
QIANG WU
(281) 535-1889
QWU@ADIRES.COM
Business Contact:
KENNETH CASTLEMAN
(281) 535-1889
INFO@ADIRES.COM
Research Institution:
n/a
Abstract
The goal of this project is to develop innovative digital microscope autofocusing techniques for automated cytogenetics applications. We propose a novel multi-resolution image analysis approach to focus measurement and detection, based on the recently developed mathematical theory of wavelet transform. In comparison to currently available single-resolution techniques, the proposed method overcomes their fundamental limitations and promises considerably more accurate, reliable and faster means to compute and determine in-focus image position for image acquisition. This will significantly increase the ability and efficacy of automated scanning microscope instruments for clinical and cancer cytogenetics applications. In Phase 1 we will investigate the feasibility of the proposed method based on its utilization in fluorescence microscopy. We will develop and implement the algorithm and software for multi-resolution focus function computation and in-focus position determination. We will test and evaluate the new method against the current best-performing algorithms by comparing (1) Accuracy; (2) Range; (3) Insensitivity to other parameters; and (4) Speed. If the new approach achieves superior performance, in Phase 2 the technique will be further developed and extended to bright-field microscopy applications. When fully developed, the new technology will be made available to Applied Imaging (AIC) for integration into the PowerGene cytogenetics automation products.

* information listed above is at the time of submission.

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