SBIR/STTR Phase I: Biocompatiblization of Charged Vesicles and Colloids

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$100,000.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
58271
Agency Tracking Number:
0215279
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
535 Dentro Dr, Santa Barbara, CA, 93111
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Edward Kisak
(805) 453-0886
kisak@advancedencapsulation.com
Business Contact:
() -
Research Institution:
n/a
Abstract
This Small Business Innovation Research (SBIR) Phase I project will test the feasibility of new drug delivery applications arising from Advanced Encapsulation's patented method of lipid membrane encapsulation. This passive method has demonstrated the ability to encapsulate nearly any object of colloidal dimensions at relatively high yield under gentle conditions. Specifically, no other technique has been reported which encapsulates interior vesicles intact and having a composition distinct from the outer membrane. Cationic vesicles and iron oxide nanoparticles are all known to have poor compatibility with blood environments resulting in rapid aggregation and/or clearance. However, these materials have shown great promise in vitro for various biomedical applications including medical imaging, controlled release, and localized delivery via magnetic fields. This project will test the encapsulation and separation efficiency as well as the stability of these materials in bovine serum and/or plasma. Based on the successes of liposomes in intravenous drug delivery, and on the physics of macromolecular interactions, liposomal encapsulation should engender biocompatibility to both classes of materials in question. The commercial applications of this project are in the area of pharmaceutical drug delivery.

* information listed above is at the time of submission.

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