Novel Membrane System to Automatically Deglycerolize Thawed Frozen Human Blood

Award Information
Agency: Department of Defense
Branch: Army
Contract: N/A
Agency Tracking Number: 26623
Amount: $693,979.00
Phase: Phase II
Program: SBIR
Awards Year: 1995
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
2828 N. Crescent Ridge Drive, The Woodlands, TX, 77381
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Lucas Gordon
 (713) 363-4949
Business Contact
Phone: () -
Research Institution
N/A
Abstract
Improved methods for frozen storage of glycerolized red blood cells (RBCs) are needed both tomeet military and civilian needs in periods of high demand. Existing deglycerolization ssytems are labor intensive and considered "open" systems resulting in a maximum storage of 24hrs following washing. The washing of cells with flat sheet membrane filters has been proven effective by the Advanced Haemotechnologies PlateletPlus (TM) Autotransfusion System. They system saves RBCs and reomves >90% of plasma contaminants. If awarded, Phase I activities will include design, construction and testing of three different filter device configurations. They will include multistage continuous flow, single state whole unit, and single stage multibatch devices. Prior to testing the prototype devices, PlateletPlus (TM) filters assembled with various candidate membranes will be tested to select the optimum pore size for deglycerolization. A PlateletPlus (TM) console with modified software will control all filter devices. Tests will be performed using packaged RBCs and frozen glycerolized blood. The major goals of Phase I testing will be to demonstrate that one or more device configurations meet the following requirements: 1. Total processing time <25 minutes 2. Final Hematocrit -- approximately 40% 3. Residual glycerol <1%W/V

* Information listed above is at the time of submission. *

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