Modular Perfusion Bioreactor for Tissue Engineering

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$100,000.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-10-C-0203
Award Id:
96858
Agency Tracking Number:
O093-H11-3140
Solicitation Year:
n/a
Solicitation Topic Code:
OSD 09-H11
Solicitation Number:
n/a
Small Business Information
130 North Main Street, Suite 600, Butte, MT, 59701
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
836287680
Principal Investigator:
Todd McAdams
Principal Investigator
(406) 497-5233
tmcadams@resodyn.com
Business Contact:
Lawrence Farrar
President
(406) 497-5252
lcfarrar@resodyn.com
Research Institution:
n/a
Abstract
This project will develop and demonstrate a prototype Modular Perfusion Bioreactor (MPB) for tissue engineering applications. While many unique styles of bioreactors have been proposed for various types of stem cell and tissue cultures, there is not a single, easy-to-use device that accommodates the multiple diverse needs of multiple tissue culture types.. In order to take advantage of recent advances in stem cell culture, biomaterials, and tissue engineering techniques, Resodyn Corporation proposes to develop, design, fabricate, and test a multi-functional bioreactor platform system. As a starting point for this multi-functional system, Resodyn Corporation will use its highly scalable (50-1,500ml) and successful (>1x108 cells/ml) hypoxia perfusion bioreactor. The focus of the proposed work will be to design additional culture modules that can be plugged into an advanced platform system developed by Resodyn Corporation. Modules that allow the culture of cellular monolayers, encapsulated cells, microcarrier-attached cells, and cells attached to scaffolds of various types will be developed and tested for feasibility and applicability. The MPB system has significant long-term commercial potential both in the laboratory and the clinic as a tool to facilitate the translation of stem cell developments into practical replacement tissues for neural, hematopoietic, and mesenchymal lineages.

* information listed above is at the time of submission.

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