FERRITE PARTICLES AS NMR IMAGING CONTRAST AGENTS

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 4720
Amount: $494,000.00
Phase: Phase II
Program: SBIR
Awards Year: 1988
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Advanced Magnetics Inc.
45 Spinelli Place, Cambridge, MA, 02138
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Jerome M Lewis
 Principal Investigator
 (617) 497-2070
Business Contact
Phone: () -
Research Institution
N/A
Abstract
AS PART OF A COLLABORATIVE EFFORT WITH THE DEPARTMENT OF RADIOLOGY AT THE MASSACHUSETTS GENERAL HOSPITAL, ADVANCED MAGNETICS INTENDS TO ASSESS THE POTENTIAL OF LIVER-TARGETED,FERRITE-BASED CONTRAST AGENTS TO ENHANCE THE POTENTIAL OF MAGNETIC RESONANCE (MR) IMAGING FOR DETECTION OF LIVER METASTASES USING A RAT TUMOR MODEL. ALTHOUGH MOST STUDIES WITH MR CONTRAST AGENTS HAVE INVOLVED ONLY IONS OR ION- CHELATE COMPLEXES, SOME RECENT RESEARCH SUGGESTS THAT SUCH FERRITE PARTICLES CAN ACT AS POWERFUL IMAGE ENHANCEMENT CONTRAST AGENTS. ONE PROMISING TYPE OF CANDIDATE PARTICLE HAS BEEN IDENTIFIED. EFFORTS WILL BE DIRECTED TOWARD THE SYSTEMATIC SYNTHESIS OF A VARIETY OF FERRITE COMPOUNDS THAT ARE CONTROLLED FOR PARTICLE SIZE, FERRITE COMPOSITION, AND CHEMICAL COATING. THESE PARAMETERS ARE DIRECTED TOWARD PRODUCING A NON-TOXIC, PARTICULATE (COLLOIDAL) CONTRAST AGENT(S) OF CONTROLLED SIZE, SIZE DISTRIBUTION, AND CHEMICALCOATING WHOSE SURFACE PROPERTIES WILL ALLOW FOR THE EFFICIENT PHAGOCYTOSIS BY THE RETICULOENDOTHELIAL SYSTEM OF THE LIVER BUT NOT BY TUMOR NODULES. THE RESULT OF THIS SELECTIVE UPTAKE SHOULD ALLOW MAJOR IMPROVEMENTS IN THE CONTRAST BETWEEN NORMAL AND CANCEROUS TISSUES. NEW MR CONTRAST AGENTS WILL PROVIDE ADDITIONAL TOOLS FOR THE STUDY OF ORGAN PHYSIOLOGY AND METABOLISM AND OFFER CLINICAL ADVANTAGES THAT CAN RESULT IN INCREASED PATIENT/SAMPLE THROUGHPUT AND REDUCED COST PER EXAMINATION.

* information listed above is at the time of submission.

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