Mouse Neuro-Recorder Headstage for Wide-band Microelectrode Signals

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R43MH085376-01
Agency Tracking Number: MH085376
Amount: $326,478.00
Phase: Phase I
Program: SBIR
Awards Year: 2009
Solicitation Year: 2009
Solicitation Topic Code: N/A
Solicitation Number: PHS2009-2
Small Business Information
DUNS: 927303412
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (763) 463-4814
Business Contact
Phone: (763) 463-4814
Research Institution
DESCRIPTION (provided by applicant): AME proposes to develop and build a multi-channel wideband neuro-recorder headstage that can be used for measuring and recording action potentials in mice. The neuro-recorder will use miniature flash-based memory to store data locally and transfer them to a PC post-testing. Currently available neuro-recording headstages only record local field potentials on mice and do not have enough bandwidth or memory to record action potential data. The proposed head stage will advance the state-of-the-art in ambulatory animal neurological monitoring and enable new neurological research. Despite being traditionally difficult to instrument due to their small size, mice are desirable subjects because they are genetically manipulable. This allows mice to accommodate scientific experiments that are unavailable in other species, such as rats. This proposed device will support detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease and epilepsy. PUBLIC HEALTH RELEVANCE: This device will enable detailed animal neurological studies, which support numerous research areas including Alzheimer's, Huntington's disease, and epilepsy.

* Information listed above is at the time of submission. *

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