XENON POLARIZATION TRANSFER CONTRAST MRI OF LUNG

Award Information
Agency:
Department of Health and Human Services
Branch:
N/A
Amount:
$98,757.00
Award Year:
2002
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA094442-01
Agency Tracking Number:
CA094442
Solicitation Year:
N/A
Solicitation Topic Code:
N/A
Solicitation Number:
N/A
Small Business Information
ADVANCED MRI TECHNOLOGY, LLC
ADVANCED MRI TECHNOLOGY, LLC, 652 PETALUMA AVE, STE J, SEBASTOPOL, CA, 95472
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
N/A
Principal Investigator
 KAI RUPPERT
 (707) 829-2933
 KAI.RUPPERT@ADVANCEDMRI.COM
Business Contact
 DAVID FEINBERG
Phone: (707) 829-2340
Email: DAVID.FEINBERG@ADVANCEMRI.COM
Research Institution
N/A
Abstract
We are proposing the development of an MRI pulse sequence package based on the recently invented Xenon Polarization transfer Contrast (XTC) MRI. Upon inhalation of a batch of hyperpolarized 129Xe, the lipophilic xenon dissolves almost instantaneously in the lung tissue and the blood. Although only a small fraction of the gas (ca. 2 percent) is dissolved at any point in time it is nevertheless standing in fast exchange with the much larger gas pool in the air spaces of the lung. Selective destruction of the magnetization of the dissolved 129Xe with the application of a series of frequency selective radio frequency pulses that leave The gas phase magnetization undisturbed makes it possible to encode certain physiological parameters of the parenchyma as intensity variations in the gas phase images The proposed precise characterization of the exchange parameters and their variability in healthy subjects as well as the maximization of the available dynamic range are the key steps for a successful MRI pulse sequence implementation. These results will permit the development of a novel, noninvasive in-viva diagnostic tool that can be sensitized for a range of pathological changes in the lung morphology or function.

* information listed above is at the time of submission.

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