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Non-Invasive, Continuous, Transdermal Glucose Monitor w/Actuator Control

Award Information
Agency: Department of Defense
Branch: Office of the Secretary of Defense
Contract: DAMD17-03-C-0048
Agency Tracking Number: O022-0461
Amount: $99,989.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Solicitation Year: N/A
Award Year: 2002
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
39255 Country Club Drive, Suite B-12
Farmington Hills, MI 48331
United States
DUNS: 014443423
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 Hal Cantor
 President & CTO
 (248) 553-9375
Business Contact
 Hal Cantor
Title: President & CTO
Phone: (248) 553-9375
Research Institution

"AST proposes to develop a non-invasive methodology able to continuously monitor blood glucose concentration. As opposed to employing near infrared spectroscopy, which suffers from the limitations of sensitivity, stability, and repeatability, AST intendsto employ direct measurement of glucose, via amperometric sensors coated with glucose oxidase membranes, from minute amounts of interstitial fluid obtained transdermally. AST's proposed transdermal sampling system, with incorporated micro-fluidics andmicro-sensor technologies, will provide the capability to transduce the concentration of glucose, as well as other biological molecules including blood electrolytes, hormones, therapeutic drugs, etc., in near real-time with the potential for closed-loopfeedback control to administer appropriate drugs or sound an alarm (via auditory, visual, or telemetric communication), while weighing only a few grams. Glucose concentration in blood can be used to determine metabolic status as well as asses the degreeof stress a person is under. When AST's device is outfitted with closed-loop control capabilities, automated infusion of insulin can be achieved in the effort to maintain euglycemia at all times, with insulin presentation in a near-physiological temporalmanner. This process, "intensive therapy" for diabetes management, appears to offer the greatest hope of preventing diabetic complications by achieving tight control of blood glucose conce

* Information listed above is at the time of submission. *

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