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Real-Time Melatonin Monitor to Diagnose Sleep Disorder

Award Information
Agency: Department of Health and Human Services
Branch: National Institutes of Health
Contract: 2R44MH062852-02
Agency Tracking Number: MH062852
Amount: $916,895.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: N/A
Solicitation Number: N/A
Timeline
Solicitation Year: N/A
Award Year: 2003
Award Start Date (Proposal Award Date): N/A
Award End Date (Contract End Date): N/A
Small Business Information
ADVANCED SENSOR TECHNOLOGIES 39255 COUNTRY CLUB DR, STE B-12
FARMINGTON HILLS, MI 48331
United States
DUNS: N/A
HUBZone Owned: No
Woman Owned: No
Socially and Economically Disadvantaged: No
Principal Investigator
 HAL CANTOR
 (248) 553-9375
 HCANTOR@ADVENSORTECH.COM
Business Contact
 HAL CANTOR
Phone: (248) 553-9375
Email: HCANTOR@ADVSENSORTECH.COM
Research Institution
N/A
Abstract

DESCRIPTION (provided by applicant): With an ever-growing elderly population, it is becoming increasingly important to monitor physiological correlates associated with age. One major problem associated with age revolves around quantity and quality of sleep. Many commercial devices monitor physiometric nocturnal activity (i.e. actigraphy, EEG, EMG, EOG, respiration, etc.), however, there are no commercial devices available for continuous, non-invasive, near real-time monitoring of chemicals in the blood. The pineal hormone, melatonin, follows a characteristic circadian temporal pattern. Plasma melatonin concentrations are utilized as a correlate indicating sleep, and exogenous application has been utilized in the attempt to improve the quality and quantity of sleep. Contemporary studies on the causal effects of melatonin on sleep require drawing of blood, saliva, or urine, however, each of these techniques require effort on the part of the subject, causing deviation from normal sleep patterns. In this Phase II project, AST proposes to fabricate a continuous, near real-time, non-invasive monitor
for blood borne chemicals, including melatonin (as well as a myriad of other biological molecules), obtained during activity or sleep. This device will be amenable to mass screening of the elderly (and pediatric) population, with the potential for actuator regulated exogenous melatonin administration. The device is also applicable to the monitoring of glucose with closed-loop controlled injection of insulin in the attempt to achieve euglycemia at all times.

* Information listed above is at the time of submission. *

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