HIGH-RESOLUTION TOOLS FOR ATOMIC FORCE MICROSCOPY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
19264
Agency Tracking Number:
19264
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
6009 Knyghton Road, Indianapolis, IN, 46220
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Donald A Chernoff
(317) 251-1364
Business Contact:
() -
Research Institute:
n/a
Abstract
THE PURPOSE OF THIS PROJECT IS TO IMPROVE THE RESOLUTION OF THE ATOMIC FORCE MICROSCOPE (AFM). EXISTING PROBES FOR AFMS ARE RELATIVELY BLUNT AT THE END (RADIUS OF CURVATURE CA. 50 NM), LIMITING INSTRUMENTAL RESOLUTION AND MAKING IMAGE INTERPRETATION DIFFICULT WHEN EXAMINING MACROMOLECULAR STRUCTURES (LENGTH SCALE 1-100 NM). WE WILL DEPOSIT MOLECULAR-SCALE CLUSTERS OF CONTROLLED SIZE (1-5 NM DIAMETER) ON COMMERCIALLY AVAILABLE AFM PROBES. THESE CLUSTERS WILL THEN SERVEAS SHARPER PROBE TIPS. WE WILL DEPOSIT MOLECULAR-SCALE CLUSTERS ON FLAT SUBSTRATES, WHICH WILLTHEN SERVE AS TEST OBJECTS TO EXAMINE THE INSTRUMENTAL RESPONSE FUNCTION OF THE AFM. THE AVAILABILITY OF SHARPER PROBE TIPS AND OF RESOLUTION-TESTING SPECIMENS WILL AID STRUCTURAL CHARACTERIZATION AND MATERIALS DEVELOPMENT IN A WIDE RANGE OF FIELDS WHICH DEPEND ON UNDERSTANDING AND/OR CONTROLLING THE FUNCTION OF NANOMETER-SCALE STRUCTURES. IN BIOLOGY AND MEDICINE, FAVORABLE IMPACTS ARE EXPECTED FOR STUDIES OF: DNA SEQUENCES, TRANSMEMBRANE CHANNELS, CELLULAR RECEPTORS AND ASSEMBLIES OF STRUCTURAL POLYMERS, AS WELL AS IN TESTING SEQUENCES, TRANSMEMBRANE CHANNELS, CELLULAR RECEPTORS AND ASSEMBLIES OF STRUCTURAL POLYMERS, AS WELL AS IN TESTING THE BIOCOMPATIBILITY OF VARIOUS MATERIALS. IN OTHER DISCIPLINES, MATERIALS CHARACTERIZATION WILL BE AIDED IN STUDIES OF CATALYSIS AND NANOELECTRONICS.

* information listed above is at the time of submission.

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