POLYETHYLENE OXIDE STAR MOLECULES AS THROMBORESISTANT SURFACES

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: N/A
Agency Tracking Number: 19336
Amount: $50,000.00
Phase: Phase I
Program: SBIR
Awards Year: 1992
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
Advanced Surface
9 Linnell Circle, Billerica, MA, 01821
DUNS: N/A
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Ih-houng Loh
 (508) 663-7652
Business Contact
Phone: () -
Research Institution
N/A
Abstract
BLOOD IN CONTACT WITH AN ARTIFICIAL SURFACE CAN LEAD TO SHORT-TERM PLATELET DEPOSITION, ACTIVATION AND THROMBOSIS, AND TO COAGULATION VIA ACTIVATION OF THE INTRINSIC CLOTTING SYSTEMS. LONG-TERM EFFECTS MAY RESULT IN COMPLEMENT ACTIVATION. THIS RESEARCH CENTERS ON UTILIZING A NEW CLASS OF PEOP MOLECULES, IN THE FORM OF STARS, TO ACCOMPLISH TWO THINGS: (1) COMPLETELY COVER THE UNDERLYING SUPPORT MATERIAL SO THAT IT CANNOT BE ACCESSED BY ANY OF THE PRECURSORS OF THROMBOSIS, COAGULATION OR COMPLEMENT ACTIVATION. THIS SHOULD PRODUCE A "NON-THROMBOGENIC" SURFACE, BUT NOT AN "ANTI-THROMBOGENIC" SURFACE. (2) TO PROVIDE AT THE SAME TIME MOLECULAR "LEASHES" (I.E,, PEO CHAINS), AT THE ENDS OF WHICH ARE COVALENTLY ATTACHED A MOLECULAR SUCH AS HEPARIN WHICH WILL CARRY OUT A SPECIFIC INTERACTION WITH BLOOD. THIS IS AN EXAMPLE OF A (POTENTIALLY) ANTITHROMBOGENIC SURFACE.

* information listed above is at the time of submission.

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