POLYETHYLENE OXIDE STAR MOLECULES AS THROMBORESISTANT SURFACES

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1992
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
19336
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Advanced Surface
9 Linnell Circle, Billerica, MA, 01821
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Ih-houng Loh
(508) 663-7652
Business Contact:
() -
Research Institution:
n/a
Abstract
BLOOD IN CONTACT WITH AN ARTIFICIAL SURFACE CAN LEAD TO SHORT-TERM PLATELET DEPOSITION, ACTIVATION AND THROMBOSIS, AND TO COAGULATION VIA ACTIVATION OF THE INTRINSIC CLOTTING SYSTEMS. LONG-TERM EFFECTS MAY RESULT IN COMPLEMENT ACTIVATION. THIS RESEARCH CENTERS ON UTILIZING A NEW CLASS OF PEOP MOLECULES, IN THE FORM OF STARS, TO ACCOMPLISH TWO THINGS: (1) COMPLETELY COVER THE UNDERLYING SUPPORT MATERIAL SO THAT IT CANNOT BE ACCESSED BY ANY OF THE PRECURSORS OF THROMBOSIS, COAGULATION OR COMPLEMENT ACTIVATION. THIS SHOULD PRODUCE A "NON-THROMBOGENIC" SURFACE, BUT NOT AN "ANTI-THROMBOGENIC" SURFACE. (2) TO PROVIDE AT THE SAME TIME MOLECULAR "LEASHES" (I.E,, PEO CHAINS), AT THE ENDS OF WHICH ARE COVALENTLY ATTACHED A MOLECULAR SUCH AS HEPARIN WHICH WILL CARRY OUT A SPECIFIC INTERACTION WITH BLOOD. THIS IS AN EXAMPLE OF A (POTENTIALLY) ANTITHROMBOGENIC SURFACE.

* information listed above is at the time of submission.

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