STTR Phase I: Multifunctional Nanoparticle Assemblies for Optical Diagnosis and Treatment of Disease

Award Information
Agency:
National Science Foundation
Branch
n/a
Amount:
$149,869.00
Award Year:
2009
Program:
STTR
Phase:
Phase I
Contract:
0930423
Award Id:
91209
Agency Tracking Number:
0930423
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2200 Kraft Drive, Blacksburg, VA, 24060
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
800610128
Principal Investigator:
JasonRidley
PhD
(540) 250-6603
millerm@vnanot.com
Business Contact:
JasonRidley
PhD
(540) 250-6603
millerm@vnanot.com
Research Institute:
VA Polytechnic Inst. & State Univ
Linda Bucy
1880 Pratt Drive
Suite 2006
Blaksburg, VA, 24060 5702
(540) 231-5281
Nonprofit college or university
Abstract
This award is funded under the American Recovery and Reinvestment Act of 2009 (Public Law 111-5). This Small Business Technology Transfer (STTR) Phase I project will develop a new class of multifunctional nanoparticle assemblies for optical disease diagnosis and treatment. The nanoparticle assemblies will be synthesized using a new plasmon-enhanced two-photon activated crosslinking approach that will attach nanoparticles with an unprecedented level of selectivity towards specific nanoparticle sites. Through incorporation of organic chromophores, the plasmonic resonances of the metallic nanoparticles will provide three to six orders of magnitude enhancement in the efficiency of second harmonic imaging microscopy and two-photon excitation fluorescence microscopy, which will be utilized for imaging the locations of disease states such as cancerous tumors within the body. Increased laser intensity combined with the energy concentration of the plasmonic hotspots into small spatial volumes will enable hyperthermal treatment of the disease through large increases in the local temperature. The broader impacts of this research include acceleration of the development of optical techniques for diagnosis and treatment of diseases such as cancer. While such optical techniques are under intense research and development for implementation in biomedicine, the orders of magnitude increases in efficiency provided by the new nanoparticle assemblies proposed here will enable more rapid implementation. Furthermore, the novel approach for synthesis of nanoparticle assemblies will have a much broader scientific and commercial impact. The assembly method only requires that one of the nanoparticles be metallic. The development of this new assembly approach will thus enable the combination of a wide range functionalities including magnetic nanoparticles, antimicrobial silver nanoparticles, and fluorescent quantum dots.

* information listed above is at the time of submission.

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