Pneumoreductive Surfactant Therapy for Emphysema

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 2R44HL077961-02
Agency Tracking Number: HL077961
Amount: $855,484.00
Phase: Phase II
Program: SBIR
Awards Year: 2006
Solitcitation Year: 2006
Solitcitation Topic Code: N/A
Solitcitation Number: PHS2006-2
Small Business Information
AERIS THERAPEUTICS, INC.
AERIS THERAPEUTICS, INC., 10K GILL ST, WOBURN, MA, 01801
Duns: N/A
Hubzone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 EDWARD INGENITO
 (781) 937-0110
 eingenito@aerist.com
Business Contact
 EDWARD INGENITO
Phone: (781) 937-0110
Email: EINGENITO@AERIST.COM
Research Institution
N/A
Abstract
DESCRIPTION (provided by applicant): Aeris therapeutics is developing a novel medical treatment for patients with advanced emphysema known as Pneumoreductive Surfactant (PRS). PRSs are inhaled drugs that increase lung recoil by safely altering the surface tension properties of native lung surfactant. Unlike existing medical therapies for chronic obstructive pulmonary disease, PRS is the only medical therapy designed specifically to treat emphysema by improving lung recoil and decreasing hyperinflation. During Phase I SBIR funding (9/2004 to 3/2005), Aeris identified two PRS formulations that favorably alter lung surfactant function in vitro, and effectively increase lung recoil in emphysema models in vivo. The best of these preparations has been selected for product development. Dose-response and dose delivery studies demonstrate that PRSs can be effectively delivered to the lung using conventional nebulizer systems. Repeat dosing studies confirm the safety of PRS administration, out to two weeks. GMP sources of raw materials for manufacturing PRS have been identified, and a manufacturing protocol, clinical plan, and regulatory strategy have been developed for advancing this product into clinical testing. Aeris is requesting Phase II SBIR support to advance the development of this exciting new therapeutic product.

* information listed above is at the time of submission.

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