SBIR Phase I:Scale-up Manufacturing of Nitric Oxide Nanotechnology for Healthcare Infections

Award Information
Agency: National Science Foundation
Branch: N/A
Contract: 1013531
Agency Tracking Number: 1013531
Amount: $140,761.00
Phase: Phase I
Program: SBIR
Awards Year: 2010
Solicitation Year: 2010
Solicitation Topic Code: NM
Solicitation Number: NSF 09-609
Small Business Information
PO Box 110023, Durham, NC, 27709
DUNS: 621609556
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Nathan Stasko
 (919) 485-8080
Business Contact
 Nathan Stasko
Title: PhD
Phone: (919) 485-8080
Research Institution
This Small Business Innovation Research (SBIR) Phase I project aims to develop a scale-up manufacturing process of nitric oxide-releasing silica nanoparticles. The main challenge is controlling the nanoparticle crystal size while maintaining high levels of nitric oxide storage. In this project, critical process parameters including reactant addition rate, reaction temperature and mixing rate will be studied. The Balanced-Nucleation and Growth (BNG) Model will be utilized to transform process data into predictors of controlled particle size. The broader/commercial impact of this project will be the potential to provide large-volume nitric oxide-releasing silica nanoparticles for placement in products aimed at the prevention and treatment of infectious diseases. Availability of large-quantity nitric oxide-releasing silica nanoparticles is important to combat the rising number of nosocomial infections. However, the necessary scale-up technology to manufacture nitric oxide-releasing silica nanoparticles is not available. This project is expected to provide the processes to manufacture large quantities of nitric oxide-releasing silica nanoparticles for anti-infective product development.

* Information listed above is at the time of submission. *

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