"AN IN VITRO BIOASSAY FOR ESTROGENS AND ANTIESTROGENS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$484,858.00
Award Year:
1993
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
16483
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Aeron Biotechnology, Inc.
1933 Davis Street, Suite 310, San Leandro, CA, 94577
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Zava, David T
Principal Investigator
(415) 461-2369
Business Contact:
1 R43 HD27738-01
() -
Research Institution:
n/a
Abstract
WE WILL DEVELOP A SIMPLE, ECONOMICAL, AND RAPID IN VITRO BREAST CANCER CELL BIOASSAY THAT CAN BE USED TO DETECT, DISTINGUISH BETWEEN, AND DETERMINE THE BIOACTIVITY OF ESTROGENS AND ANTIESTROGENS. TO DISTINGUISH BETWEEN ESTROGENS AND ANTIESTROGENS WE WILL MONITOR DIFFERENCES IN THEIR MOLECULAR ACTIONS ON ESTROGEN RECEPTOR (ER) BINDING AND ACTIVATION, ER PROCESSING, END PRODUCT INDUCTION, AND CELL PROLIFERATION IN INTACT BREAST CANCER CELL LINES. THE IN VITRO BIOASSAY WILL HAVE SEVERAL COMMERCIAL APPLICATIONS. IT WILL PROVIDE A SIMPLE MEANS BY WHICH A LARGE PANEL OF DRUGS, PLANT EXTRACTS, FOODSTUFFS, ETC. CAN BE SCREENED RAPIDLY FOR ESTROGENIC OR ANTIESTROGENIC (I. E. ANTICANCER) ACTIVITY. AT THE CLINICAL LEVEL THE BIOASSAY WILL BE USEFUL FOR MONITORING SERUM ANTIESTROGEN CONTENT AND OVERALL BIOACTIVITY IN BREAST CANCER PATIENTS RECEIVING ANTIESTROGEN THERAPY.

* information listed above is at the time of submission.

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