Labeless, Reagentless, Biosensor

Award Information
Agency:
Department of Defense
Branch
Office for Chemical and Biological Defense
Amount:
$100,000.00
Award Year:
1998
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
40388
Agency Tracking Number:
40388
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
117 Devlen Rd, Groton, NY, 13073
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr. Carl A. Batt
(607) 255-2890
Business Contact:
() -
Research Institution:
n/a
Abstract
The preponderance of biosensors under development today rely on labeling reagents such as fluorescent, radioisotopic or enzymatic tags. As a result, the added complexity of these reagents and their incorporation into the detection system has resulted in designs that are difficult to implement or that require significant sample preparation steps before introduction into the detection instrument. While increasing signal, these labels also increase noise, can negatively impact on specificity and overall in the signal-to-noise ratio. In short, the need for reagents by current systems has created significant obstacles to fielding a truly portable, reliable and easy to use biosensor, i.e., one that can be used by the warfighter without significant training or preparation. To meet these needs, Agave BioSystems proposes to develop a truly labeless and reagentless biosensor based upon the optical diffraction of analyte bound to reflective silicon. Key to this effort is the innovative, proprietary microcontact printing technology of Agave BioSystems and its collaborator. This technology allows the precise placement of arrays of biological recognition molecules to form gratings which coupled with optical defraction allows the reagentless detection of multiple targets.

* information listed above is at the time of submission.

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