Fluorogenic Cell-Based Biosensors for Microbial Monitoring

Award Information
Agency:
National Aeronautics and Space Administration
Branch
n/a
Amount:
$70,000.00
Award Year:
2001
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
NASA1597
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Agave BioSystems, Inc.
PO Box 80010, Austin, TX, 78708
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Joel Tabb
Senior Scientist
(607) 255-8479
jtabb@agavebio.com
Business Contact:
Noe Salazar
President
(512) 671-1369
nsalazar@agavebio.com
Research Institution:
n/a
Abstract
Great strides have been made in developing diagnostic systems for detecting and identifying specific pathogens and their toxins. However, these systems may be too specific and unable to detect newly emerging pathogens whose immunological or genetic profile is different than the normal complement of pathogens. The ideal system in an isolated environment such as a spacecraft would be one that provided a warning if any pathogen is present. In this Phase I effort, we propose to engineer chimeric proteins that fuse CD14 bacterial binding protein and the Fc portion of IgE antibodies. These novel bacterial receptors will bind to both mast cells and a large variety of pathogenic bacteria, enabling the mast cells to sense very low levels of contaminating bacteria from a diverse population. Using a compact yet highly sensitive fluorometer, this innovative biological receptor and signal transduction system will provide detection capability for a wide variety of pathogens in a single small and lightweight biosensor. This sensor will have applications in a number of testing regiments including being able to detect bacteria present in water, food, surfaces and the spacecraft air supply.

* information listed above is at the time of submission.

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