Fluorogenic Cell-Based Biosensors for Microbial Monitoring

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NAS9-02019
Agency Tracking Number: 001597
Amount: $0.00
Phase: Phase I
Program: SBIR
Awards Year: 2002
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
PO Box 80010, Austin, TX, 78708
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Joel Tabb
 Senior Scientist
 (607) 255-8479
Business Contact
 Noe Salazar
Title: President
Phone: (512) 671-1369
Email: nsalazar@agavebio.com
Research Institution
Great strides have been made in developing diagnostic systems for detecting and identifying specific pathogens and their toxins. However, these systems may be too specific and unable to detect newly emerging pathogens whose immunological or genetic profile is different than the normal complement of pathogens. The ideal system in an isolated environment such as a spacecraft would be one that provided a warning if any pathogen is present. In this Phase I effort, we propose to engineer chimeric proteins that fuse CD14 bacterial binding protein and the Fc portion of IgE antibodies. These novel bacterial receptors will bind to both mast cells and a large variety of pathogenic bacteria, enabling the mast cells to sense very low levels of contaminating bacteria from a diverse population. Using a compact yet highly sensitive fluorometer, this innovative biological receptor and signal transduction system will provide detection capability for a wide variety of pathogens in a single small and lightweight biosensor. This sensor will have applications in a number of testing regiments including being able to detect bacteria present in water, food, surfaces and the spacecraft air supply.

* Information listed above is at the time of submission. *

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