Enabling Drug Discovery for Malaria

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$730,000.00
Award Year:
2003
Program:
SBIR
Phase:
Phase II
Contract:
DAMD17-03-C-0014
Award Id:
63101
Agency Tracking Number:
A022-1487
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.O. Box 80010, Austin, TX, 78708
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
022552900
Principal Investigator:
JoelTabb
Principal Scientist
(607) 272-0002
jtabb@agavebio.com
Business Contact:
NoeSalazar
President
(512) 671-1369
nsalazar@agavebio.com
Research Institute:
n/a
Abstract
Agave BioSystems has been highly successful in accomplishing the Phase I objectives. In this Phase II proposal, Agave BioSystems will build upon the results generated in the Phase I to isolate additional shikimate pathway genes. We will continue to usestate-of-the-art-bioinformatics computational analysis to assist in identifying genes in this pathway. We will also continue our use of both genetic and functional approaches for gene isolation. The genes for these enzymes will then be cloned into aheterologous system such as E. coli so that the enzymes can be overexpressed and purified. Additionally, rapid, highly sensitive biochemical assays for these enzymes will be developed for screening of potential drug libraries. The development of methodsfor identifying and isolating genes from Plasmodium, as well as biochemical assays for the shikimate pathway genes, will greatly enhance the rate at which drugs can be screened for potential anti-malarial activity. As a result of the successful completionof both the Phase I and Phase II programs, Agave BioSystems will have established the core technology to validate genes isolated from a particular group of organisms and express and isolate them in recombinant form to enable drug discovery. This processcan then be used to develop drugs for other significant pathogens.The import of the information is reflected in the prevalence and mortality resulting from malaria (300 million cases, 1 million deaths per year). Thus, the commercial value of any information that could serve as the foundation for anti-malarial drugdevelopment is extremely high. Organizations that could benefit from this Phase I project include not only pharmaceutical companies, but also federal agencies and international organizations engaged in fighting tropical illnesses.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government