Organic Thin Film Transistor for Bioterrorism Pathogen Detection

Award Information
Agency: Department of Defense
Branch: Navy
Contract: N00014-03-M-0137
Agency Tracking Number: N022-1161
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2003
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
P.O. Box 80010, Austin, TX, 78708
DUNS: 022552900
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Joel Tabb
 Principal Scientist
 (607) 272-0002
 jtabb@agavebio.com
Business Contact
 Noe Salazar
Title: President
Phone: (512) 671-1369
Email: nsalazar@agavebio.com
Research Institution
N/A
Abstract
It is clear now that deadly biological materials can easily be spread throughout the U.S., and that there are few methods currently available to rapidly detect and identify these bioterrorist agents. Significant resources have been applied to thedevelopment of DNA diagnostic systems for this purpose but, to date, these systems are limited in their ability to accurately and reliably detect small quantities of target DNA and require a relatively lengthy processing period involving amplification ofeither the target or a downstream signal and are susceptible to false positives. An optimal detection system would allow for direct target DNA detection without an intervening amplification step.Agave BioSystems, in collaboration with Cornell University, proposes to construct a novel and highly sensitive organic semiconductor-based DNA detection system that will have a theoretical detection limit of a single copy of target. This detection systemwill utilize organic thin film transistors and will be completely independent of any biologically-based amplification steps. In this Phase I, we will provide proof of concept for the novel detection mechanism through the microfabrication and testing ofsensing components. Potential diagnostic markets include medical, food safety, environmental, agricultural, as well as forensics, law enforcement and the military. Relevant examples of DNA diagnostic applications include the detection of bioterrorismagents, identification of multi-drug resistant bacteria in patient samples, determination of food pathogens and molecular typing of personnel.

* Information listed above is at the time of submission. *

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