WGM Resonators for Proteomic Analysis

Award Information
Agency: National Aeronautics and Space Administration
Branch: N/A
Contract: NNM04AA64C
Agency Tracking Number: 034155
Amount: $70,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2004
Solicitation Year: 2003
Solicitation Topic Code: B1.02
Solicitation Number: N/A
Small Business Information
Agave BioSystems Inc
401 E. State St., Ithaca, NY, 14850-4409
DUNS: 022552900
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Joel Tabb
 Principal Investigator
 (607) 272-0002
 jtabb@agavebio.com
Business Contact
 Noe Salazar
Title: Business Official
Phone: (512) 671-1369
Email: nsalazar@agavebio.com
Research Institution
N/A
Abstract
Due to the extensive amounts of data generated from the genome sequencing projects, the focus of genomics has shifted from elucidating DNA sequence to the interpretation of gene function. In addition, as proteins are most often the targets of drugs, a method of studying the genome at the protein level is fueling the pharmaceutical industry?s interest in proteomics. By interpreting the interacting partners of a protein of interest and stimuli that affect these conditions, much can be learned about the protein?s function. To help fuel the proteomics revolution, Agave BioSystems, in collaboration with Dr. Robert Boyd, of the Institute of Optics at the University of Rochester, proposes to develop an ultra sensitive analytical tool based on whispering gallery mode (WGM) resonator technology for the detection of protein-protein interactions. Simulations have demonstrated that WGM resonator technology can provide several orders of magnitude greater sensitivity as compared to current detection mechanisms such as SPR. The microfabrication of this detection mechanism, coupled with microfluidic systems to be developed in the Phase II, will result in a disposable biochip that can be readily used in a small, compact and portable instrument.

* information listed above is at the time of submission.

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