Portable Cell Maintenance System

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$98,953.00
Award Year:
2004
Program:
STTR
Phase:
Phase I
Contract:
W81XWH-04-C-0140
Agency Tracking Number:
A045-028-0194
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
AGAVE BIOSYSTEMS, INC.
P.O. Box 80010, Austin, TX, 78708
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
022552900
Principal Investigator:
Theresa Curtis
Staff Scientist
(607) 272-0002
tcurtis@agavebio.com
Business Contact:
Noe Salazar
President
(512) 671-1369
nsalazar@agavebio.com
Research Institution:
Cornell University
Linda Brainard
Office of Sponsored Projects, 123 Day Hall
Ithaca, NY, 14854
(607) 255-7123
Nonprofit college or university
Abstract
Cultured cell-based biosensors offer insight into the physiological action of the agent of interest, which is an advantage over other types of sensors. The development of cell-based biosensors that are field-portable would increase their utility in toxicology and environmental monitoring. One of the most significant issues hampering the development of field portable cell-based biosensors is the maintenance of optimal cultured cell environment under field conditions. A key technology to overcoming this issue is the use of microfluidic systems. A microfluidic based systems would allow assaying small quantities of sample while optimizing storage and transport conditions by minimizing the overall systems size and fluid monitoring requirements. In this Phase I, Agave BioSystems and Cornell University propose to develop a cell maintenance system (CMS) with integrated pH, osmilarity, CO2 and temperature sensors to support multiple vertebrate cells and cell types under field conditions. In addition, a microfluidic cell cartridge suitable for use in hand-held devices and fabricated from biocompatible materials will be developed that is inexpensive and disposable. The proposed CMS would maintain vertebrate cell viability and sterility through transport, storage, and testing and be compatible with interfaces for acquisition and analysis of cell signaling data relevant to toxicity identification.

* information listed above is at the time of submission.

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