Portable Cell Maintenance System

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-04-C-0140
Agency Tracking Number: A045-028-0194
Amount: $786,967.00
Phase: Phase II
Program: STTR
Awards Year: 2005
Solitcitation Year: 2004
Solitcitation Topic Code: A04-T028
Solitcitation Number: N/A
Small Business Information
AGAVE BIOSYSTEMS, INC.
P.O. Box 80010, Austin, TX, 78708
Duns: 022552900
Hubzone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Theresa Curtis
 Senior Scientist
 (607) 272-0002
 tcurtis@agavebio.com
Business Contact
 Noe Salazar
Title: President
Phone: (512) 671-1369
Email: nsalazar@agavebio.com
Research Institution
 CORNELL UNIV.
 Linda Brainard
 123 Day Hall, Cornell Universi
Ithaca, NY, 14854
 (607) 255-7123
 Nonprofit college or university
Abstract
Cultured cell-based biosensors offer insight into the physiological action of the agent of interest, which is an advantage over other types of sensors. The development of cell-based biosensors that are field-portable would increase their utility in toxicology and environmental monitoring. One of the most significant issues hampering the development of field portable cell-based biosensors is the maintenance of optimal cultured cell environment under field conditions. In the Phase I work, Agave BioSystems and Cornell University successfully demonstrated proof of concept for a cell maintenance system (CMS) with integrated pH, osmolarity, CO2 and temperature sensors to support multiple vertebrate cells and cell types. In the Phase I CMS instrument demonstration, endothelial cells, fibroblast cells, and neuronal networks were supported for at least 3 days. In the proposed Phase II effort, a compact, portable and rugged prototype cell maintenance system will be developed and constructed with integrated monitoring and environmental control. The system will be designed to maintain a variety of cell types for more than 30 days.

* information listed above is at the time of submission.

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