Portable Cell Maintenance System

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$750,000.00
Award Year:
2005
Program:
STTR
Phase:
Phase II
Contract:
W81XWH-04-C-0140
Award Id:
68464
Agency Tracking Number:
A045-028-0194
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.O. Box 80010, Austin, TX, 78708
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
022552900
Principal Investigator:
TheresaCurtis
Senior Scientist
(607) 272-0002
tcurtis@agavebio.com
Business Contact:
NoeSalazar
President
(512) 671-1369
nsalazar@agavebio.com
Research Institute:
CORNELL UNIV.
Linda Brainard
123 Day Hall, Cornell Universi
Ithaca, NY, 14854
(607) 255-7123
Nonprofit college or university
Abstract
Cultured cell-based biosensors offer insight into the physiological action of the agent of interest, which is an advantage over other types of sensors. The development of cell-based biosensors that are field-portable would increase their utility in toxicology and environmental monitoring. One of the most significant issues hampering the development of field portable cell-based biosensors is the maintenance of optimal cultured cell environment under field conditions. In the Phase I work, Agave BioSystems and Cornell University successfully demonstrated proof of concept for a cell maintenance system (CMS) with integrated pH, osmolarity, CO2 and temperature sensors to support multiple vertebrate cells and cell types. In the Phase I CMS instrument demonstration, endothelial cells, fibroblast cells, and neuronal networks were supported for at least 3 days. In the proposed Phase II effort, a compact, portable and rugged prototype cell maintenance system will be developed and constructed with integrated monitoring and environmental control. The system will be designed to maintain a variety of cell types for more than 30 days.

* information listed above is at the time of submission.

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