Magnetic Nanoparticles and Quantum Dots for Diagnosis of Early Stage Ovarian Canc

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$300,000.00
Award Year:
2010
Program:
SBIR
Phase:
Phase I
Contract:
1R43CA154339-01
Award Id:
95951
Agency Tracking Number:
CA154339
Solicitation Year:
n/a
Solicitation Topic Code:
NCI
Solicitation Number:
n/a
Small Business Information
OCEAN NANOTECH, LLC, 2143 Worth Lane, SPRINGDALE, AR, -
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
155516987
Principal Investigator:
ZORAIDA AGUILAR
(479) 751-5500
ZAGUILAR@OCEANNANOTECH.COM
Business Contact:
ALICE BU
() -
AWANG@OCEANNANOTECH.COM
Research Institution:
n/a
Abstract
DESCRIPTION (provided by applicant): Ocean NanoTech proposes to develop a portable, sensitive, high throughput, low cost, and user friendly system for the early stage diagnosis of ovarian cancer using magnetic nanoparticles (MNPs), quantum dots (QDs), and a nanoelectrode array (NEA) all integrated in a disposable lab-on-a-chip. The proposed system will consists of a fully automated instrument that requires a disposable lab-on-a-chip device that uses very sensitive high quantum yield quantum dots and nanoele ctrode array for signal generation in the diagnosis of stage I levels of ovarian cancer biomarkers at concentrations potentially d 1 ng/mL in a d 60 min assay. It will be fully automated allowing high throughput analysis, high sensitivity with gt 95% relia bility, and minimizing false positives and false negatives. Unlike existing diagnostic methods of ovarian cancer which are either invasive or detect biomarkers too late in the progress of the disease leading to very low survival rate, the proposed system i s anticipated to detect early stages of the disease which is the most promising approach to the long term survival of ovarian cancer patients. The proposed system is anticipated to diagnose early stage ovarian cancer that can be used for the following very important purposes: 1) regular monitoring of high risk women; 2) diagnose early stage of the disease at the onset of vague clinical symptoms; 3) monitor changes in the ovarian cancer biomarker levels during medication; and 4) detection system during the d evelopment and efficacy testing of drugs, vaccine, or other therapeutic molecules. PUBLIC HEALTH RELEVANCE: Our goal is to develop a portable, sensitive, high throughput, low cost, and user friendly system for the early stage diagnosis of ovarian ca ncer that uses a disposable lab-on-a-chip that integrates the advantages of magnetic nanoparticles (MNPs), quantum dots (QDs), and nanoelectrode array (NEA) for fluorescence as well as nanoelectrochemical detection. We will develop the best combination of MNPs, QDs, and NEA for isolation and detection of multiple ovarian cancer biomarkers for early diagnosis and possible early treatment of approximately 20,000 American women who are diagnosed with ovarian cancer and of whom 15,000 die each year.

* information listed above is at the time of submission.

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