Microfluidic Optical Biosensor for Detection of Biowarfare Agents

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$100,000.00
Award Year:
2006
Program:
STTR
Phase:
Phase I
Contract:
W9132T-06-C-0029
Agency Tracking Number:
A064-026-0240
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
AGAVE BIOSYSTEMS, INC.
P.O. Box 80010, Austin, TX, 78708
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
022552900
Principal Investigator:
Joel Tabb
(607) 272-0002
jtabb@agavebio.com
Business Contact:
Noe Salazar
President
(512) 671-1369
nsalazar@agavebio.com
Research Institution:
THE UNIV. OF ROCHESTER
Robert Boyd
The Institute of Optics
Rochester, NY, 14627
(585) 275-2329
Nonprofit college or university
Abstract
This STTR Phase I project will develop a microfluidic optical biosensor based on whispering gallery mode resonator technology for the detection of bioterrorism agents. The proposed device will bridge biological sciences with optics and material sciences to develop a commerically useful tool for homeland security. This microfluidic optical biosensor proposed by Agave BioSystems, in collaboration with Dr. Robert Boyd of the Institute of Optics at the University of Rochester, has the potential to detect low levels of pathogens within minutes after air sampling has been completed and will not be prone to the ambiguous results associated with PCR based detection technologies. The device relies on measuring the direct absorption of biological materials on the whispering gallery mode resonators by monitoring their effect on the light resonating within its microcavity. The proposed device will respond to the specific capture of Bacillus anthracis spores by antibodies on the resonator surface. By coupling the detection mechanism to a microfluidic delivery system, the device will have the potential to be automated and rely on small sample volumes. The microfluidics will be designed and fabricated at the wafer-level using glass wafer etching to embrace the current trend in the microsystems industry.

* information listed above is at the time of submission.

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