Dipstick Assay for Field Detection of Leishmania Parasites using Quantum Dots

Award Information
Agency:
Department of Defense
Branch
Office of the Secretary of Defense
Amount:
$100,000.00
Award Year:
2005
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-05-C-0094
Agency Tracking Number:
O043-H08-3058
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
AGAVE BIOSYSTEMS, INC.
P.O. Box 80010, Austin, TX, 78708
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
022552900
Principal Investigator:
Theresa Curtis
Staff Scientist
(607) 272-0002
tcurtis@agavebio.com
Business Contact:
Noe Salazar
President
(512) 671-1369
nsalazar@agavebio.com
Research Institution:
n/a
Abstract
A PCR based assay has been developed to detect Leishmania parasites, but PCR requires sophisticated laboratory instruments and trained personnel to interpret the data. The parasite can also be identified in infected sand flies by skillful dissection and microscopic examination but this is subjective and not appropriate for field testing. Antibodies are available that can detect Leishmania parasites and a standard ELISA could be used for detection, but this like the other assays requires trained personnel and sophisticated laboratory instruments. To overcome these shortcomings, Agave BioSystems proposes to develop a dipstick assay to provide a practical tool for assessment of Leishmania infected sand flies in the field. Our novel dipstick assay would use new fluorescent quantum dot technology for detection. This quantum dot assay would be considerably more specific, sensitive, and stable making it superior to standard colorimetric dipstick assays.

* information listed above is at the time of submission.

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