Ribozymes for In Vivo Degradation of G-Nerve Agents

Award Information
Agency:
Department of Defense
Branch
Office for Chemical and Biological Defense
Amount:
$70,000.00
Award Year:
2008
Program:
SBIR
Phase:
Phase I
Contract:
FA8650-08-M-6914
Award Id:
86065
Agency Tracking Number:
C081-108-0086
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.O. Box 80010, Austin, TX, 78708
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
022552900
Principal Investigator:
Janet Huie
Staff Scientist
(607) 272-0002
jhuie@agavebio.com
Business Contact:
Noe Salazar
President
(512) 656-6200
nsalazar@agavebio.com
Research Institute:
n/a
Abstract
Given the possibility to administer prophylactic doses of protein bioscavengers inactivating OP nerve agents before they reach their acetylcholinesterase target, much attention has been given to proteins such as human butyrylcholinesterase and paraoxonase I. As small nucleic acid catalysts can exhibit triphosphoesterase activities, the identification of new molecules active against nerve agents would constitute a significant breakthrough for the development of a biopharmaceutical approach against OP agents, with rapid optimization of catalytic rate, stability, large-scale production, storage and formulation. In this Phase I, Agave BioSystems proposes to develop novel catalytically active oligonucleotides against G-nerve agents using high throughput selection in E. coli. The development of a high-throughput selection method in E. coli to identify novel RNA molecules able to hydrolyze nerve agents constitutes a promising and innovative approach. Unlike other methods typically used for the de novo creation of new RNA or DNA catalysts, this in vivo approach will directly identify molecules combining favorable binding and dissociation constants, as well as strong catalytic activity.

* information listed above is at the time of submission.

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