Point-of-Care Diagnostic for Acute Q Fever using LAMP
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100, Ithaca, NY, 14850
AbstractQ fever is caused by the bacterium Coxiella burnetii and presents with acute symptoms indistinguishable from many other blood infections. Chronic infection, however, can result in endocarditis, with a high mortality rate (up to 60% of chronic Q fever cases) and requiring open-heart surgery to repair substantial valve damage in many cases. Q fever can be airborne or tick-borne, and is associated with sheep and other livestock. Q fever is a significant factor in deployment conditions in Iraq and Afganistan. It is important to diagnose Q fever during its acute phase to direct appropriate treatment and to identify personnel requiring follow-up monitoring for chronic disease. While serology tests have been commercialized for Q fever detection, it is necessary to test both IgG and IgM against two types of Coxiella burnetii antigens to differentiate between acute and chronic disease stages. In addition, a high false positive rate occurs for these assays. To eliminate these shortcomings, Agave BioSystems proposes to modify a loop-mediated isothermal amplification (LAMP) reaction built into a point-of-care primitive field diagnostic device.
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