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Point-of-Care Diagnostic for Acute Q Fever using LAMP

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-09-C-0036
Agency Tracking Number: A083-178-0472
Amount: $120,000.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: A08-178
Solicitation Number: 2008.3
Solicitation Year: 2008
Award Year: 2009
Award Start Date (Proposal Award Date): 2009-01-20
Award End Date (Contract End Date): 2010-04-15
Small Business Information
P.O. Box 100
Ithaca, NY 14850
United States
DUNS: 022552900
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Janet Huie
 Staff Scientist
 (607) 272-0002
Business Contact
 Noe Salazar
Title: President
Phone: (512) 656-6200
Research Institution

Q fever is caused by the bacterium Coxiella burnetii and presents with acute symptoms indistinguishable from many other blood infections. Chronic infection, however, can result in endocarditis, with a high mortality rate (up to 60% of chronic Q fever cases) and requiring open-heart surgery to repair substantial valve damage in many cases. Q fever can be airborne or tick-borne, and is associated with sheep and other livestock. Q fever is a significant factor in deployment conditions in Iraq and Afganistan. It is important to diagnose Q fever during its acute phase to direct appropriate treatment and to identify personnel requiring follow-up monitoring for chronic disease. While serology tests have been commercialized for Q fever detection, it is necessary to test both IgG and IgM against two types of Coxiella burnetii antigens to differentiate between acute and chronic disease stages. In addition, a high false positive rate occurs for these assays. To eliminate these shortcomings, Agave BioSystems proposes to modify a loop-mediated isothermal amplification (LAMP) reaction built into a point-of-care primitive field diagnostic device.

* Information listed above is at the time of submission. *

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