Point-of-Care Diagnostic for Acute Q Fever using LAMP

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$70,000.00
Award Year:
2009
Program:
SBIR
Phase:
Phase I
Contract:
W81XWH-09-C-0036
Award Id:
92028
Agency Tracking Number:
A083-178-0472
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
P.O. Box 100, Ithaca, NY, 14850
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
022552900
Principal Investigator:
JanetHuie
Staff Scientist
(607) 272-0002
jhuie@agavebio.com
Business Contact:
NoeSalazar
President
(512) 656-6200
nsalazar@agavebio.com
Research Institute:
n/a
Abstract
Q fever is caused by the bacterium Coxiella burnetii and presents with acute symptoms indistinguishable from many other blood infections. Chronic infection, however, can result in endocarditis, with a high mortality rate (up to 60% of chronic Q fever cases) and requiring open-heart surgery to repair substantial valve damage in many cases. Q fever can be airborne or tick-borne, and is associated with sheep and other livestock. Q fever is a significant factor in deployment conditions in Iraq and Afganistan. It is important to diagnose Q fever during its acute phase to direct appropriate treatment and to identify personnel requiring follow-up monitoring for chronic disease. While serology tests have been commercialized for Q fever detection, it is necessary to test both IgG and IgM against two types of Coxiella burnetii antigens to differentiate between acute and chronic disease stages. In addition, a high false positive rate occurs for these assays. To eliminate these shortcomings, Agave BioSystems proposes to modify a loop-mediated isothermal amplification (LAMP) reaction built into a point-of-care primitive field diagnostic device.

* information listed above is at the time of submission.

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