Point-of-Care Diagnostic for Acute Q Fever using LAMP

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-09-C-0036
Agency Tracking Number: A083-178-0472
Amount: $120,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2009
Solitcitation Year: 2008
Solitcitation Topic Code: A08-178
Solitcitation Number: 2008.3
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100, Ithaca, NY, 14850
Duns: 022552900
Hubzone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Janet Huie
 Staff Scientist
 (607) 272-0002
Business Contact
 Noe Salazar
Title: President
Phone: (512) 656-6200
Email: nsalazar@agavebio.com
Research Institution
Q fever is caused by the bacterium Coxiella burnetii and presents with acute symptoms indistinguishable from many other blood infections. Chronic infection, however, can result in endocarditis, with a high mortality rate (up to 60% of chronic Q fever cases) and requiring open-heart surgery to repair substantial valve damage in many cases. Q fever can be airborne or tick-borne, and is associated with sheep and other livestock. Q fever is a significant factor in deployment conditions in Iraq and Afganistan. It is important to diagnose Q fever during its acute phase to direct appropriate treatment and to identify personnel requiring follow-up monitoring for chronic disease. While serology tests have been commercialized for Q fever detection, it is necessary to test both IgG and IgM against two types of Coxiella burnetii antigens to differentiate between acute and chronic disease stages. In addition, a high false positive rate occurs for these assays. To eliminate these shortcomings, Agave BioSystems proposes to modify a loop-mediated isothermal amplification (LAMP) reaction built into a point-of-care primitive field diagnostic device.

* information listed above is at the time of submission.

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