Water Toxicity Detection using Genetically Engineered Yeast

Award Information
Agency: Department of Defense
Branch: Army
Contract: W81XWH-09-C-0073
Agency Tracking Number: A083-174-0418
Amount: $120,000.00
Phase: Phase I
Program: SBIR
Awards Year: 2009
Solicitation Year: 2008
Solicitation Topic Code: A08-174
Solicitation Number: 2008.3
Small Business Information
Agave BioSystems, Inc.
P.O. Box 100, Ithaca, NY, 14850
DUNS: 022552900
HUBZone Owned: Y
Woman Owned: N
Socially and Economically Disadvantaged: Y
Principal Investigator
 Kathie Berghorn
 Staff Scientist
 (607) 272-0002
 kberghorn@agavebio.com
Business Contact
 Noe Salazar
Title: President
Phone: (512) 656-6200
Email: nsalazar@agavebio.com
Research Institution
N/A
Abstract
The rapid evaluation of drinking water toxicity in the field is a necessity for the safety of our soldiers. To achieve field portability and sensitive screening for identification of toxic industrial chemicals (TICs) a handheld device that is biologically-based and easy to use with components that remain viable for 6 months would be ideal. In this Phase I, Agave BioSystems proposes to develop an accurate and efficient cell-based biosensor using engineered yeast to rapidly evaluate toxicity in drinking water. This methodology will use Saccharomyces cerevisiae yeast measuring two different outcomes to ensure TIC detection accuracy. This novel yeast strain will be lyophilized for long term storage and is expected to be responsive to a variety of TICs.

* information listed above is at the time of submission.

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