Treatment of Sepsis with Talactoferrin

Award Information
Agency: Department of Health and Human Services
Branch: N/A
Contract: 1R44GM077816-01A2
Agency Tracking Number: GM077816
Amount: $570,399.00
Phase: Phase I
Program: SBIR
Awards Year: 2007
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
DUNS: 808956700
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 (713) 552-1091
Business Contact
Phone: () -
Research Institution
DESCRIPTION (provided by applicant): Severe sepsis is a major cause of morbidity and mortality throughout the world. It is the leading cause of death in non-coronary intensive care units (ICUs) in the United States, with more than 750,000 cases occurring e very year. This means that in the United States, more than 500 patients die from severe sepsis every day, with 28% to 50% of the patients succumbing to the disease process at an average cost of 22,000 per patient. Successful development of TLF-based thera py for sepsis would satisfy a significant unmet medical need. Agennix has now established a manufacture of a pharmaceutical-grade talactoferrin, it has demonstrated its safety in clinical studies for various indications, and is now interacting with the FDA to obtain a go-ahead to initiate clinical Phase 3 studies in cancer. The development of talactoferrin is therefore at a stage that a demonstration of its clinical efficacy in sepsis would put the generation of a product to treat sepsis on a relatively eas y and straightforward path.

* Information listed above is at the time of submission. *

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