Biocatalytic Polymer Skin Adhesives

Award Information
Agency: Department of Defense
Branch: Army
Contract: DAAD19-02-C-0010
Agency Tracking Number: A2-0029
Amount: $494,666.00
Phase: Phase II
Program: STTR
Awards Year: 2001
Solicitation Year: N/A
Solicitation Topic Code: N/A
Solicitation Number: N/A
Small Business Information
AGENTASE LLC
3636 Boulevard of the Allies, Suite B-17, Pittsburgh, PA, 15213
DUNS: 041791695
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Keith LeJeune
 (412) 209-7298
Business Contact
 Keith LeJeune
Phone: (412) 209-7298
Research Institution
 MIDWEST RESEARCH INSTITUTE
 Jeanette Tombaugh
 425 Volker Boulevard
Kansas City, MO, 64110
 (816) 753-7600
 Domestic nonprofit research organization
Abstract
This Phase II STTR proposal describes the development of a prototype enzyme-containing adhesive capable of attaching biocatalytic activity directly to skin. The adhesive, when containing organophosphorus-hydrolyzing enzymes, shall serve to protectunderlying skin from otherwise toxic applications of nerve agents and pesticides. Agentase, a recognized world leader in developing polymer-based carriers for enzyme catalysis, in collaboration with the Midwest Research Institute, shall demonstrate thefeasibility of providing personal protection from hazardous chemicals to individuals via enzyme-based skin adhesives.Having successfully demonstrated the viability of synthesizing biocatalytic adhesives with significant enzyme activity and excellent physical properties during Phase I, Phase II activity is directed at developing a prototype adhesive for protection againstOPs. More specifically, proposed work includes optimization of the processes for applying adhesives in a reproducible and uniform fashion, enhancing their capacity for decontamination, and ensuring polymer as well as polymerization compatibility with skintissues. Phase II research shall also provide a clear demonstration that enzyme-containing skin adhesives can be effectively used to protect a small animal model from the debilitating effects of OP exposures. Successful completion of the aims describedin this Phase II STTR proposal will provide a novel biopolymer skin adhesive for protection against organophosphorus contamination from nerve agents and pesticides. The addition of active biomolecules, such as enzymes, to a skin-compatible biopolymeradhesive has great potential in facilitated wound healing.

* information listed above is at the time of submission.

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