Biocatalytic Polymer Skin Adhesives

Award Information
Agency:
Department of Defense
Branch
Army
Amount:
$494,666.00
Award Year:
2001
Program:
STTR
Phase:
Phase II
Contract:
DAAD19-02-C-0010
Agency Tracking Number:
A2-0029
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
AGENTASE LLC
3636 Boulevard of the Allies, Suite B-17, Pittsburgh, PA, 15213
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
041791695
Principal Investigator:
Keith LeJeune
(412) 209-7298
Business Contact:
Keith LeJeune
(412) 209-7298
Research Institution:
MIDWEST RESEARCH INSTITUTE
Jeanette Tombaugh
425 Volker Boulevard
Kansas City, MO, 64110
(816) 753-7600
Domestic nonprofit research organization
Abstract
This Phase II STTR proposal describes the development of a prototype enzyme-containing adhesive capable of attaching biocatalytic activity directly to skin. The adhesive, when containing organophosphorus-hydrolyzing enzymes, shall serve to protectunderlying skin from otherwise toxic applications of nerve agents and pesticides. Agentase, a recognized world leader in developing polymer-based carriers for enzyme catalysis, in collaboration with the Midwest Research Institute, shall demonstrate thefeasibility of providing personal protection from hazardous chemicals to individuals via enzyme-based skin adhesives.Having successfully demonstrated the viability of synthesizing biocatalytic adhesives with significant enzyme activity and excellent physical properties during Phase I, Phase II activity is directed at developing a prototype adhesive for protection againstOPs. More specifically, proposed work includes optimization of the processes for applying adhesives in a reproducible and uniform fashion, enhancing their capacity for decontamination, and ensuring polymer as well as polymerization compatibility with skintissues. Phase II research shall also provide a clear demonstration that enzyme-containing skin adhesives can be effectively used to protect a small animal model from the debilitating effects of OP exposures. Successful completion of the aims describedin this Phase II STTR proposal will provide a novel biopolymer skin adhesive for protection against organophosphorus contamination from nerve agents and pesticides. The addition of active biomolecules, such as enzymes, to a skin-compatible biopolymeradhesive has great potential in facilitated wound healing.

* information listed above is at the time of submission.

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