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Oxytocin: Improving measurement sensitivity and specificity

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-14-C-0004
Agency Tracking Number: D132-001-0089
Amount: $149,838.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code: SB132-001
Solicitation Number: 2013.2
Timeline
Solicitation Year: 2013
Award Year: 2014
Award Start Date (Proposal Award Date): 2013-11-25
Award End Date (Contract End Date): 2014-11-22
Small Business Information
220 Reservoir Street, Suite 3, Needham Hgts, MA, 02494-3133
DUNS: 809963895
HUBZone Owned: N
Woman Owned: Y
Socially and Economically Disadvantaged: N
Principal Investigator
 Ranganathan Shashidhar
 Senior Vice President
 (781) 449-2284
 rshashidhar@polestartech.com
Business Contact
 Daniel Wattendorf
Title: program manager
Phone: (703) 526-4085
Email: daniel.wattendorf@darpa.mil
Research Institution
N/A
Abstract
This SBIR Phase I Proposal aims to develop a detection method for enabling sensitive and specific measurement of oxytocin, particularly to discriminate between the 9- and 12- amino acid versions. It aims to demonstrate the feasibility of a novel hybrid molecular imprinting device that can accomplish the overall goals of the program. The technical approach will use the knowledge that the peptide conformations and charges can be tuned by experimental conditions such as pH and ion concentration as well as by the high affinity and specificity of molecular interactions. It will also use ac impedance technology and surface imprinting technique to achieve high sensitivity. Phase I results are expected to demonstrate a capability of distinguishing the 9- and 12-amino acid versions of oxytocin in Phosphate Buffered Saline (PBS) at less than 0.25 pg/ml level.

* Information listed above is at the time of submission. *

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