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Oxytocin: Improving measurement sensitivity and specificity

Award Information
Agency: Department of Defense
Branch: Defense Advanced Research Projects Agency
Contract: W31P4Q-15-C0011
Agency Tracking Number: D2-1364
Amount: $1,485,464.00
Phase: Phase II
Program: SBIR
Solicitation Topic Code: SB132-001
Solicitation Number: 2013.2
Timeline
Solicitation Year: 2013
Award Year: 2014
Award Start Date (Proposal Award Date): 2014-10-31
Award End Date (Contract End Date): 2017-01-30
Small Business Information
220 Reservoir Street, Suite 3
Needham Hgts, MA 02494-3133
United States
DUNS: 809963895
HUBZone Owned: No
Woman Owned: Yes
Socially and Economically Disadvantaged: No
Principal Investigator
 Ranganathan Shashidhar
 Vice President
 (781) 449-2284
 rshashidhar@polestartech.com
Business Contact
 Daniel Wattendorf
Title: program manager
Phone: (703) 526-4085
Email: daniel.wattendorf@darpa.mil
Research Institution
N/A
Abstract

In this Phase II program Polestar Technologies Inc. will fabricate a prototype system based on the principles demonstrated in Phase I and demonstrate its capability for specific and sensitive detection of both the 9-aminoacid and the 12-aminoacid forms of Oxytocin. During Year 1 of our Phase II program, a first generation prototype will be fabricated and optimized for all the three steps involved. We will also assess the sensitivity for detection using synthetically prepared oxytocin solutions for concentrations ranging from 2 ? 200 pg/mL concentrations. During Year 2, Polestar will fabricate and test a beta prototype and demonstrate its capability of measuring both forms of Oxytocin levels in both blood samples and saliva samples. Finally, in the Option period of the program, detailed clinical studies will be conducted in collaboration with Professor Karen Bales of the University of California at Davis (UC Davis). These studies will include 30 young adults which will be subjected to a series of standard tasks to induce stress. The blood and saliva samples from these subjects will be collected before and after the stress. The oxytocin levels in these samples will be measured and compared with the oxytocin levels of the control (before stress) samples.

* Information listed above is at the time of submission. *

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