MAJOR OBJECTIVES OF THIS RESEARCH ARE TO (1) ISOLATE 100 MG OF HOMOGENEOUS DIHYDROFOLATE REDUCTASE (DHFR) FROM CANDIDA ALBICANS, (2) CRYSTALLIZE THE ENZYME, AND (3) DETERMINE ITS THREE-DIMENSIONAL STRUCTURE USING X-RAY DIFFRACTION METHODS.

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Agency Tracking Number:
4682
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Agouron Technology Corp
505 Coast Blvd South, La Jolla, CA, 92037
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
DAVID A MATTHEWS
PRINCIPAL INVESTIGATOR
(619) 456-1623
Business Contact:
() -
Research Institution:
n/a
Abstract
MAJOR OBJECTIVES OF THIS RESEARCH ARE TO (1) ISOLATE 100 MG OF HOMOGENEOUS DIHYDROFOLATE REDUCTASE (DHFR) FROM CANDIDA ALBICANS, (2) CRYSTALLIZE THE ENZYME, AND (3) DETERMINE ITS THREE-DIMENSIONAL STRUCTURE USING X-RAY DIFFRACTION METHODS.ARMED WITH THE RESULTING DETAILED KNOWLEDGE OF THE GEOMETRICAL AND TOPOGRAPHICAL PROPERTIES OF CANDIDAS DHFR INRELATION TO THE KNOWN STRUCTURE OF THE CORRESPONDING VERTEBRATE ENZYME, AGOURON TECHNOLOGY WILL DESIGN SPECIFIC, PHARMACOLOGICALLY ACTIVE INHIBITORS THAT SELECTIVELY CRIPPLETHE BACTERIAL REDUCTASE WITHOUT INTERFERING WITH ONE-CARBON METABOLISM IN THE HOST. SUCH NOVEL INHIBITORS WILL ADDRESS THE CURRENT NEED FOR NEW ANTI-INFECTIVE AGENTS WITH ENHANCEDANTI-CANDIDAL ACTIVITY AGAINST CANDIDA ALBICANS.

* information listed above is at the time of submission.

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