RETARDATION

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1986
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
4828
Agency Tracking Number:
4828
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
505 Coast Blvd South, La Jolla, CA, 92037
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
CILA BLATT
PRINCIPAL INVESTIGATOR
(619) 456-1623
Business Contact:
() -
Research Institute:
n/a
Abstract
THIS PROJECT DESCRIBES THE ISOLATION OF DNA PROBES LINKED TOTHE SITE IN THE HUMAN X CHROMOSOME INVOLVED IN FRAGILITY OF THE CHROMOSOME UNDER SOME GROWTH CONDITIONS ("FRAGILE X SITE") AND KNOWN TO BE ASSOCIATED WITH A HIGH INCIDENCE OF MENTAL RETARDATION. SUCH SEQUENCES MAY BE USEFUL IN UNDER- STANDING THE MOLECULAR DEFECTS RESPONSIBLE FOR CHROMOSOMAL FRAGILITY, IN ELUCIDATING THE PATHOGENESIS OF THE CENTRAL NERVOUS SYSTEM DISORDER, AND IN PROVIDING TOOLS FOR ITS DETECTION. RESEARCHERS WILL INVESTIGATE THE POSSIBILITY THAT LARGE REGIONS OF THE HUMAN AND MOUSE X CHROMOSOMES HAVESIMILAR OR IDENTICAL GENETIC ORGANIZATION AND DETERMINE THE FINE STRUCTURE GENETIC MAP OF THE REGION OF THE MOUSE X CHROMOSOME HOMOLOGOUS TO THE HUMAN FRAGILE SITE AND ITS FLANKING REGIONS. A COMBINATION OF IN SITU HYBRIDIZATION, MAPPING IN RECOMBINANT INBRED (RI) MOUSE STRAINS, AND LINKAGE ANALYSIS IN HUMAN PEDIGREES WILL BE USED TO TEST ANDPROVE TIGHT LINKAGE OF PROBES TO THE FRAGILE X SITE. THE NEW METHODS OF CHROMOSOME "WALKING" WILL THEN BE USED TO ISOLATE SEQUENCES THAT SPAN THS SITE ITSELF.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government