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High-Throughput Low-Cost Manufacturing of Engineered MRI Contrast Agents

Award Information
Agency: Department of Commerce
Branch: National Institute of Standards and Technology
Contract: 70NANB15H292
Agency Tracking Number: 031.01.03-2015
Amount: $99,619.00
Phase: Phase I
Program: SBIR
Solicitation Topic Code:
Solicitation Number: N/A
Solicitation Year: 2015
Award Year: 2015
Award Start Date (Proposal Award Date): 2015-09-15
Award End Date (Contract End Date): 2016-03-15
Small Business Information
5611 Roosevelt Street, Bethesda, MD, 20817
DUNS: 809594661
HUBZone Owned: N
Woman Owned: N
Socially and Economically Disadvantaged: N
Principal Investigator
 Lamar Mair
 (202) 568-1608
Business Contact
 Irving Weinberg
Phone: (301) 346-7944
Research Institution
Scalable manufacturing of micro-engineered MRI contrast agents has the potential to increase the specificity and resolution of imaging techniques, while reducing morbidity. Currently, techniques used for making such particles are expensive and labor intensive. In Phase I, Weinberg Medical Physics will validate techniques for rapid, massively parallel fabrication of microscale contrast agents (including shells, disks, and doubledisks). In order to demonstrate the utility of the proposed approach, they will build three different contrast agents (with shapes similar to those reported in NIST publications), demonstrate contrast agent monodispersity, mechanical stability (during processing steps typically encountered in clinical dose preparation), NMR shift uniformity, and feasibility of automated manufacturing.

* Information listed above is at the time of submission. *

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