Medical Food Cocktail for Alzheimer's Disease

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$747,700.00
Award Year:
2009
Program:
SBIR
Phase:
Phase II
Contract:
2R44AT003025-02
Award Id:
79725
Agency Tracking Number:
AT003025
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
AKESO HEALTH SCIENCES, LLC, 4607 LAKEVIEW CYN, #561, WESTLAKE VILLAGE, CA, 91361
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
170634179
Principal Investigator:
CURTHENDRIX
(818) 386-1826
CHENDRIX@SOCAL.RR.COM
Business Contact:
CURTHENDRIX
() -
chendrix@socal.rr.com
Research Institute:
n/a
Abstract
DESCRIPTION (provided by applicant): More than 4.5 million Americans currently suffer from Alzheimer's Disease, a progressive neurodegenerative disease characterized by loss of memory, changes in personality, agitation, disorientation, loss of coordination , and finally, total loss of day-to-day functioning. Alzheimer's is a staggeringly expensive disease, costing the American economy more than 83.9 billion annually. The Alzheimer's Association estimates that by 2050 between 11.3 million and 16 million Amer icans will be Alzheimer's victims, and that the overall economic impact of the disease will increase four-fold. Much of the cost of Alzheimer's is born by Medicare and Medicaid. There is currently no treatment that halts the overall progression of the dise ase. As such, there is a great need for a significant breakthrough in Alzheimer's prevention and treatment. There is a growing consensus that Alzheimer's is a multifactorial disease and it is possible that a cocktail of medicines or ingredients may be ne eded to successfully delay its onset or progression. The Akeso Health Sciences (Akeso) medical food cocktail is composed of standardized herbal extracts, vitamins, and minerals that are demonstrated in the basic science and clinical medical literature to i mpact the biochemical and pathophysiological processes involved in Alzheimer's Disease. During Phase I of this SBIR project, the investigators formulated the cocktail and conducted initial feasibility tests on cognitive function in a transgenic mouse model of Alzheimer's Disease. The medical food cocktail was effective in preventing cognitive decline and reducing Alzheimer's-related neuropathology compared to transgenic mice on regular mouse chow only. Normal non-transgenic mice fed the cocktail exhibited i mproved cognitive function. For Phase II of this SBIR project, the investigators propose to test the efficacy of the cocktail in improving cognitive function in several animal models of Alzheimer's Disease that exhibit more advanced Alzheimer's-related neu ropatholgies and severe neuronal loss. The cocktail will be tested in 2 additional transgenic mouse models and in a longitudinal study in an aged canine model. If such a medical food cocktail proves feasible and cost effective for use as a complementary or alternative therapy for Alzheimer's Disease, the devastating economical and societal costs of Alzheimer's may be drastically reduced. PUBLIC HEALTH RELEVANCE: Building on the results of a successful Phase I SBIR project, the investigators propose to test the efficacy of a medical food cocktail consisting of standardized herbal extracts, vitamins, and minerals in improving cognitive function in several animal models of Alzheimer's Disease. If effective for use as a complementary or alternative therapy, the medical food cocktail may drastically reduce the devastating economical and societal costs of Alzheimer's Disease.

* information listed above is at the time of submission.

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