Product Formulation and Process Design for Commercial Production of Soluable Phytosterols

Award Information
Agency:
Department of Agriculture
Branch
n/a
Amount:
$296,000.00
Award Year:
2006
Program:
SBIR
Phase:
Phase II
Contract:
2006-33610-17273
Agency Tracking Number:
2004-00347
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Aktiv-Dry, LLC
6060 Spine Road, Boulder, CO, 80301
Hubzone Owned:
N
Socially and Economically Disadvantaged:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Brian Quinn
(303) 350-3060
bquinn@aktiv-dry.com
Business Contact:
Brian Quinn
President
(303) 350-3060
bquinn@aktiv-dry.com
Research Institution:
n/a
Abstract
Commercially available products rich in phytosterol may now be used to cut serum low-density lipoprotein by as much as 14 percent. Unfortunately, phytosterols are poorly soluble and therefore present unique problems concerning their ability to suppress cholesterol absorption in the gut. This impediment often leads to sub-optimal dosing and poor performance of phytosterol compounds and restricts their use in nutraceuticals and functional food products. One promising approach to enhancing the dissolution rate of such compounds is to formulate them as micro- and nano-size particles. The purpose of this Phase II SBIR is to produce amorphous phytosterol powders with rates of dissolution in water and body fluids that significantly exceed what is currently available in the commercial market. We will also demonstrate the physical stability of the amorphous particles over an 18 month shelf life. Finally, the Phase II work will provide an engineering design and analysis for integrating a CAN-BD process with an existing system for manufacturing phytosterol powders on a commercial scale.

* information listed above is at the time of submission.

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