AN ADVANCED ELECTROCHEMICAL SENSOR FOR THE SIMULTANEOUS ANALYTICAL MEASUREMENT OF THREE CHEMICAL SPECIES

Award Information
Agency:
Department of Energy
Branch
n/a
Amount:
$750,000.00
Award Year:
1995
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Award Id:
27239
Agency Tracking Number:
27239
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
2810 Meridian Pkwy Suite 152, Durham, NC, 27713
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Dr Marek Wojciechowski
(919) 544-8220
Business Contact:
() -
Research Institute:
n/a
Abstract
THE REQUIREMENTS OF COMPLEX SAMPLE MONITORING PRESENT A GROWING NEED FOR A NEW GENERATION OF HIGHLY SPECIFIC ENZYME ELETRODES WITH MULTI-ANALYTE, MULTI-SIGNAL CAPABILITY. THIS PROJECT'S OBJECTIVE IS TO ESTABLISH THE FEASIBILITY OF NOVEL ELECTROCHEMICAL SENSORS BASED ON THE COMBINATION OF IMMOBILIZED ENZYMES AND COLLOIDAL GOLD TECHNOLOGIES. THE SPECIFIC GOAL TO BE PURSUED IN PHASE I IS TO DEMONSTRATE THE FEASIBILITY OF AN IN-VITRO LIPID PROFILE DIAGNOSTIC DEVICE FOR THE SIMULTANEOUS DETECTION OF TOTAL CHOLESTEROL, HIGH DENSITY LIPOPROTEINS, AND TRIGLYCERIDES USING A DISPOSABLE BIOSENSOR. THIS LIPID PROFILE TESTING IS AN IMPORTANT PART OF CURRENT RECOMMENDATIONS FOR REDUCING CARDIAC RISK AND FOR MONITORING THERAPY FOR MILLIONS OF INDIVIDUALS WITH CARDIOVASCULAR DISEASE. DEPOSITION OF COLLOIDAL GOLD WITH IMMOBILIZED ENZYMES ONTO SEPARATE CHANNELS OF A MULTI-CHANNEL SURFACE TO PROVIDE SPATIALLY RESOLVED, MULTI-SIGNAL ENZYME ELECTRODES CAN ULTIMATELY LEAD TO A NEW GENERATION OF MULTI-ANALYTE SENSORS.

* information listed above is at the time of submission.

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