VENTRICULAR FUNCTION MONITOR FOR ACTIVE PATIENTS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$248,000.00
Award Year:
1987
Program:
SBIR
Phase:
Phase II
Contract:
n/a
Agency Tracking Number:
1532
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
Radiation Monitoring Devices
44 Hunt Street, Watertown, MA, 02172
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
Gerald Entire
President
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
TO INCREASE THE BASIC UNDERSTANDING OF THE CARDIAC FUNCTION TO IMPROVE TECHNIQUES TO AID IN THE DIAGNOSIS OF HEART DISEASE. WE PROPOSE TO CONDUCT RESEARCH ON AN IMPROVED METHOD OF EVALUATING MYOCARDIAL FUNCTION IN ACTIVE PATIENTS. THIS APPROACH INVOLVES THE USE OF A VERY COMPACT, VESTLIKE INSTRUMENT WHICH USES NUCLEAR MEDICINE TECHNIQUES TO MEASURE THE EJECTION FRACTION OF THE HIGH VENTRICLE ON A BEAT BY BEAT BASIS. THE SYSTEM IS DESIGNED TO BE WORN BY AMBULATORY PATIENTS OVER AN 8 TO 16 HOUR PERIOD AND USES AN ON-BOARD CASSETTE RECORDER TO STORE BOTH THE NUCLEAR AND THE CORRESPONDING ECG DATA. THE BASIC CONCEPT, EXPLORED IN COLLABORATION WITH MASS. GENERAL HOSPITAL, APPEARS QUITE PROMISING. HOWEVER THE PRESENT NUCLEAR SENSOR IS TOO LARGE AND IS RELATIVELY INSENSITIVE TO BE SUITABLE FOR CLINICAL WORK. WE PROPOSE TO DEVELOP A NEW ALTERNATIVE SENSOR WHICH WILL BE SUFFICIENTLY SENSITIVE, RELIABLE, AND COMPACT TO MAKE THIS CONCEPT A REALITY. IN PHASE I WE WILL DEMONSTRATE THE POSSIBILITY OF MAKING SUCH SENSORS AND IN PHASE II COMPLETE THE SENSOR AND ASSOCIATED MICROELECTRONICS FOR A WORKING CLINICAL PROTOTYPE.

* information listed above is at the time of submission.

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