HYBRIDS

Award Information
Agency:
Department of Energy
Branch
n/a
Amount:
$50,000.00
Award Year:
1984
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
1181
Agency Tracking Number:
1181
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
44 Hunt Street, Watertown, MA, 02172
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
GERALD ENTINE, PH.D.
PRESIDENT
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
THE PRODUCTION OF HYBRIDOMAS BY CELL FUSION IS AN INCREASINGLY IMPORTANT ASPECT OF BOTH MEDICAL RESEARCH AND CLINICAL PROTOCOLS. IN PARTICULAR, IT HAS THE POTENTIAL FOR PROVIDING SENSITIVE DIAGNOSTIC REAGENTS TO RADIATION INDUCED CELL DAMAGE. WE HAVE RECENTLY CONDUCTED PRELIMINARY RESEARCH ON A NEW APPROACH, THE ELECTRONIC CELL FUSION TECHNIQUE. THIS TECHNIQUE USES AN ELECTRONIC IMPULSE TO PUNCTURE THE MEMBRANE AT THE POINT OF CELL CONTACT WHICH IMMEDIATELY INDUCES THE ONSET OF FUSION. THIS METHOD HAS THE POTENTIAL TO MAKE POSSIBLE THE SUCCESSFUL FUSION OF A WIDE VARIETY OF CELL PARTNERS NOT PREVIOUSLY ADDRESSABLE. RMD, INC. IN COLLABORATION WITH THE MASSACHUSETTS GENERAL HOSPITAL PROPOSES TO DO THE RESEARCH NECESSARY TO DEVELOP A RELIABLE AND PRACTICAL TECHNIQUE FOR PRODUCING AN ANTIBODY DIAGNOSTIC ASSAY TECHNIQUE FOR QUANTIFYING RADIATION INDUCED DAMAGE. IN PHASE I WE WILL FOCUS ON RESEARCH TO DEMONSTRATE BOTH THE POTENTIAL STRENGTHS OF THE ELECTRONIC CELL FUSION TECHNIQUE WITH RESPECT TO HUMAN T-CELLS. IN PHASE II, WE WILL PERFECT THE TECHNIQUE AND FIRST MAKE THE REQUIRED SPECIFIC ANTI T-CELL ANTIBODIES.

* information listed above is at the time of submission.

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