POSITRON PROBE FOR CORNEAL TUMOR BIOASSAY

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$50,000.00
Award Year:
1989
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
11162
Agency Tracking Number:
11162
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
44 Hunt St, Watertown, MA, 02172
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
RECENTLY, PRELIMINARY RESEARCH USING CYCLOTRON-PRODUCED, POSITRON-EMITTING RADIOLABELS HAS BEEN CONDUCTED AT THE MEMORIAL SLOAN-KETTERING CANCER CENTER TO DEVELOP A RABBIT/RAT CORNEAL IMPLANT METHOD TO STUDY HUMAN TUMOR ANGIOGENESIS AND METABOLISM. THIS TECHNIQUE IS DESIGNED TO DETERMINE THE DIRECT IMPACT OF CHEMOTHERAPEUTIC STRATEGIES ON HUMAN BRAIN TUMORS. IT IS HOPED THAT DRUG SCREENING FOR PATIENTS WITH GLIOMAS CAN BE CARRIED OUT WITH SUFFICIENT EFFICACY TO ACHIEVE A SUBSTANTIAL INCREASE IN THE LONG-TERM SURVIVAL RATE OF SUCH PATIENTS. TO DEVELOP SUCH A PROTOCOL, UNIQUE EQUIPMENT IS NEEDED TO MEASURE THE ACCUMULATION OF POSITRON-LABELED AMINO ACIDS WITHIN THE TUMOR WITH HIGH SENSITIVITY AND SPATIAL RESOLUTION DESPITE THE PRESENCE OF AN EXTREMELY LARGE BACKGROUND FROM THE ASSOCIATED 511-KEV GAMMA RAYS. THIS PROGRAM WILL DEVELOP A SMALL, SOLID-STATE, DUAL-ELEMENT POSITRON GAMMA PROBE SPECIFICALLY DESIGNED FOR USE WITH THE POSITRON-EMITTING ISOTOPES CENTRAL TO THE DEVELOPMENT OF THIS BIOASSAY. SUCH A LOW-COST, NONIMAGING SYSTEM THAT WILL ALLOW HIGH-QUALITY MEASUREMENTS OF METABOLIC INDICES FOR BASIC AND APPLIED MEDICAL RESEARCH WILL BE A USEFUL ADDITION TO THE CAPABILITIES OF MEDICAL CYCLOTRON GROUPS.

* information listed above is at the time of submission.

Agency Micro-sites


SBA logo

Department of Agriculture logo

Department of Commerce logo

Department of Defense logo

Department of Education logo

Department of Energy logo

Department of Health and Human Services logo

Department of Homeland Security logo

Department of Transportation logo

Enviromental Protection Agency logo

National Aeronautics and Space Administration logo

National Science Foundation logo
US Flag An Official Website of the United States Government