SOLID-STATE DETECTOR FOR CAPILLARY ELECTROPHORESIS

Award Information
Agency:
Department of Health and Human Services
Branch
n/a
Amount:
$44,946.00
Award Year:
1989
Program:
SBIR
Phase:
Phase I
Contract:
n/a
Award Id:
11462
Agency Tracking Number:
11462
Solicitation Year:
n/a
Solicitation Topic Code:
n/a
Solicitation Number:
n/a
Small Business Information
44 Hunt St, Watertown, MA, 02172
Hubzone Owned:
N
Minority Owned:
N
Woman Owned:
N
Duns:
n/a
Principal Investigator:
() -
Business Contact:
() -
Research Institution:
n/a
Abstract
GEL ELECTROPHORESIS IS ONE OF THE MOST IMPORTANT AND WIDELY USED ANALYTICAL TECHNIQUES FOR THE DETERMINATION OF THE SEQUENCE OF DNA. RECENTLY, THERE HAS BEEN A SIGNIFICANT ADVANCE IN ELECTROPHORESIS TECHNOLOGY THROUGH THE USE OF GEL GEOMETRIES INVOLVING THIN CAPILLARY TUBES. THIS TECHNOLOGY HAS BEEN DEVELOPED INTO A NEW SEPARATION TECHNIQUE, CAPILLARY ZONE ELECTROPHORESIS (CZE), WHICH PROVIDES MUCH GREATER RESOLUTION THAN TRADITIONAL GELS AND RUN SPEEDS AS MUCH AS AN ORDER OF MAGNITUDE FASTER THAN THAT ACHIEVABLE WITH THE TRADITIONAL FLAT PLATE GEOMETRY. THE CZE TECHNOLOGY IS CURRENTLY OF VERY HIGH INTEREST BECAUSE IT APPEARS TO MAKE POSSIBLE THE DEVELOPMENT OF NEW, HIGH-SPEED INSTRUMENTATION FOR DNA SEQUENCING. HOWEVER, TO MAKE FULL USE OF THIS NEW, POWERFUL SEPARATION TECHNIQUE,SEVERAL ASPECTS OF THE TECHNOLOGY REQUIRE SIGNIFICANT FURTHER DEVELOPMENT. THIS RESEARCH ADDRESSES THE NEED FOR AN IMPROVED DETECTOR SYSTEM THAT WILL ALLOW CZE TO BE USED MORE EFFECTIVELY FOR DNA SEQUENCING.

* information listed above is at the time of submission.

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